Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA6 | P23280 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Salicylate SCHEMBL9813841 | 0.84 | TSHR (0.61) | ALDH1A1KDM4EHPGDCA12CA1 | |
| Naphthoic Acid SCHEMBL9813601 | 0.81 | KMT2A (0.62) | ALDH1A1KDM4EHPGDSMN1; SMN2ALOX15 | |
| Benzoic Acid SCHEMBL9813692 | 0.81 | GAA (0.58) | KDM4ENAPRTALOX15GAAKMT2A | |
| Pyromellitic Acid SCHEMBL10684063 | 0.80 | ALOX15 (0.46) | KDM4EALOX15GAAKMT2APOLB | |
| Pyromellitic Acid SCHEMBL9813658 | 0.80 | ALOX15 (0.46) | KDM4EALOX15GAAKMT2APOLB | |
| SCHEMBL9813709 | 0.78 | ALOX15 (0.46) | ALDH1A1KDM4EHPGDALOX15CYP3A4 | |
| Phthalic Acid SCHEMBL11485468 | 0.78 | ALOX15 (0.61) | ALDH1A1KDM4EALOX15LMNACYP3A4 | |
| Salicylic Acid SCHEMBL3397874 | 0.77 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDCA12CA1 | |
| Salicylic Acid SCHEMBL6640057 | 0.76 | ALDH1A1 (0.95) | ALDH1A1KDM4EHPGDCA12CA1 | |
| Salicylic Acid SCHEMBL30554634 | 0.76 | ALDH1A1 (0.95) | ALDH1A1KDM4EHPGDCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0163245-B1 | DERIVATIVES OF ALKYL-SUBSTITUTED 4-HYDROXY-METHYL-PIPERIDINE AND USE THEREOF AS STABILIZERS | AUSIMONT S.r.l. (IT) | 1991-07-31 | — | — | EP | disclosed |
| US-4772708-A | STABILIZERS FOR POLYMERS | AUSIMONT S.P.A. (IT) | 1988-09-20 | — | — | US | disclosed |
| EP-0163245-A2 | Derivatives of alkyl-substituted 4-hydroxy-methyl-piperidine and use thereof as stabilizers | AUSIMONT S.r.l. (IT) | 1985-12-04 | — | — | EP | disclosed |