Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.52 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | BAX | Q07812 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.43 |
| ▸ | NAAA | Q02083 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58206 | 0.83 | TSHR (0.52) | TSHR | |
| SCHEMBL11506283 | 0.81 | LTA4H (0.52) | LTA4HNR1H2BAXTSHRPPARG | |
| SCHEMBL28041575 | 0.80 | LTA4H (0.52) | LTA4HNR1H2BAXTSHRPPARG | |
| SCHEMBL2088942 | 0.78 | LTA4H (0.58) | LTA4HNR1H2BAXTSHRPPARG | |
| SCHEMBL7189732 | 0.78 | IDO1 (0.57) | LTA4HTSHR | |
| SCHEMBL8994543 | 0.77 | TSHR (0.64) | LTA4HNR1H2BAXTSHRPPARG | |
| SCHEMBL891493 | 0.75 | FFAR1 (0.69) | LTA4HPPARGFFAR1FFAR4MAOA | |
| SCHEMBL8310890 | 0.74 | NQO1 (0.56) | LTA4HTSHR | |
| SCHEMBL6200077 | 0.74 | IDO1 (0.67) | LTA4HNR1H2BAXTSHRMAOA | |
| SCHEMBL2088939 | 0.74 | LTA4H (0.57) | LTA4HNR1H2BAXTSHRPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5017619-A | Anitdiabetic | HOFFMANN-LA ROCHE INC. (US) | 1991-05-21 | — | — | US | claimed |
| EP-0198412-B1 | PHENETHANOL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1989-03-22 | — | — | EP | claimed |
| US-5017619-A | Anitdiabetic | HOFFMANN-LA ROCHE INC. (US) | 1991-05-21 | — | — | US | disclosed |