Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.50 |
| ▸ | PPARA | Q07869 | 7/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.50 |
| ▸ | PTGES | O14684 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27274330 | 0.99 | PPARG (0.51) | PPARGPPARAALOX5PTGESKMT2A | |
| SCHEMBL10419970 | 0.81 | ALOX5 (0.55) | PPARGPPARAALOX5PTGESKMT2A | |
| SCHEMBL10419418 | 0.81 | ALOX5 (0.55) | PPARGPPARAALOX5PTGESKMT2A | |
| SCHEMBL10420221 | 0.81 | ALOX5 (0.55) | PPARGPPARAALOX5PTGESKMT2A | |
| SCHEMBL9814972 | 0.76 | TRPM8 (0.50) | PPARGPPARANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9614217 | 0.76 | PPARG (0.57) | PPARGPPARAALOX5PTGESKMT2A | |
| SCHEMBL10419188 | 0.76 | PPARG (0.52) | PPARGPPARAALOX5PTGESKMT2A | |
| SCHEMBL9695329 | 0.76 | PPARG (0.52) | PPARGPPARAALOX5PTGESKMT2A | |
| SCHEMBL9814917 | 0.75 | MMP2 (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2MMP2 | |
| SCHEMBL27276885 | 0.75 | TRPM8 (0.51) | PPARGPPARANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275024-B1 | CARBOXYLIC-ACID DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1991-09-04 | — | — | EP | disclosed |
| US-4833161-A | ANTIDIABETIC AGENTS, ANTICHOLESTEROL AGENTS, ANTILIPEMIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-23 | — | — | US | disclosed |
| EP-0275024-A1 | Carboxylic-acid derivatives, processes for their preparation and medicaments containing these compounds | Roche Diagnostics GmbH (DE) | 1988-07-20 | — | — | EP | disclosed |