Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 8/20 | 0.62 |
| ▸ | CNR2 | P34972 | 3/20 | 0.62 |
| ▸ | CNR1 | P21554 | 2/20 | 0.62 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13849829 | 0.93 | PTGS2 (0.61) | AKR1C3CNR2CNR1AKR1C2PTGS2 | |
| Cinmetacin SCHEMBL25139 | 0.92 | LMNA (0.68) | AKR1C3CNR2CNR1AKR1C2PTGS2 | |
| Cinmetacin SCHEMBL29974302 | 0.92 | LMNA (0.68) | AKR1C3CNR2CNR1AKR1C2PTGS2 | |
| Cinmetacin SCHEMBL25138 | 0.92 | LMNA (0.68) | AKR1C3CNR2CNR1AKR1C2PTGS2 | |
| Cinmetacin SCHEMBL8636226 | 0.91 | LMNA (0.67) | AKR1C3CNR2CNR1AKR1C2PTGS2 | |
| SCHEMBL12609001 | 0.91 | LMNA (0.58) | AKR1C3CNR2CNR1AKR1C2PTGS2 | |
| Cinmetacin SCHEMBL8636225 | 0.91 | LMNA (0.67) | AKR1C3CNR2CNR1AKR1C2PTGS2 | |
| SCHEMBL3459041 | 0.90 | PLA2G2A (0.69) | AKR1C3AKR1C2PTGS2HIF1ALMNA | |
| SCHEMBL12255244 | 0.89 | PTGS2 (0.52) | AKR1C3CNR2CNR1AKR1C2PTGS2 | |
| SCHEMBL9815439 | 0.88 | LMNA (0.53) | AKR1C3CNR2CNR1AKR1C2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | FAAH, FAAH2, AANAT | AKR1C3 970/4885CNR2 28/4885CNR1 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.