SCHEMBL9817035

SCHEMBL9817035

COc1ccc(C(c2ccc(OC)cc2)(c2ccc(O)c(-c3ccccc3)c2)c2ccc(O)c(-c3ccccc3)c2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 4/20 0.53
KDM4E B2RXH2 2/20 0.45
MAPT P10636 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
MAPK1 P28482 1/20 0.45
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
POLB P06746 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
NCOA1 Q15788 1/20 0.43
NCOA3 Q9Y6Q9 1/20 0.43
ABL1 P00519 1/20 0.42
ABCB1 P08183 1/20 0.42
BCR P11274 1/20 0.42
HDAC4 P56524 2/20 0.42
HDAC2 Q92769 2/20 0.42
HDAC8 Q9BY41 2/20 0.42
ACACA Q13085 1/20 0.41
PDE4B Q07343 2/20 0.41
PELI1 Q96FA3 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9713478 0.87 ESR1 (0.51) BACE1KDM4EMAPTSMN1; SMN2MAPK1
SCHEMBL7916383 0.85 BACE1 (0.56) BACE1KDM4EMAPTMEN1KMT2A
SCHEMBL9713890 0.83 BACE1 (0.48) BACE1KDM4EMAPTSMN1; SMN2MAPK1
SCHEMBL9817096 0.83 BACE1 (0.48) BACE1MEN1KMT2APELI1NPC1
SCHEMBL9638313 0.82 MAPT (0.60) BACE1KDM4EMAPTSMN1; SMN2MAPK1
SCHEMBL9817117 0.82 HDAC8 (0.42) BACE1MAPTSMN1; SMN2MEN1KMT2A
SCHEMBL9713261 0.82 LTA4H (0.47) BACE1KDM4EMAPTSMN1; SMN2MAPK1
SCHEMBL9713951 0.81 KIF11 (0.47) BACE1KDM4EMAPTSMN1; SMN2MAPK1
SCHEMBL9713939 0.79 KIF11 (0.51) BACE1KDM4EMAPTSMN1; SMN2MAPK1
SCHEMBL3418225 0.79 BACE1 (0.56) BACE1MAPTSMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0277627-B1 POLYFORMAL RESINS AND PROCESS FOR PRODUCING SAID RESINS IDEMITSU KOSAN COMPANY LIMITED (JP) 1991-10-23 EP disclosed
US-4801679-A Polyformal resin and process for producing said resin IDEMITSU KOSAN CO., LTD. (JP) 1989-01-31 US disclosed
EP-0277627-A1 Polyformal resins and process for producing said resins IDEMITSU KOSAN COMPANY LIMITED (JP) 1988-08-10 EP disclosed