Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | EEF2K | O00418 | 2/20 | 0.35 |
| ▸ | EEF2 | P13639 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10995168 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1ACHEBCHE | |
| SCHEMBL28888187 | 0.75 | KDM4E (0.45) | CA1CA2KDM4EALDH1A1RAB9A | |
| Fluoride SCHEMBL28721256 | 0.74 | KDM4E (0.44) | CA1CA2KDM4EALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL6892436 | 0.73 | HDAC8 (0.46) | CA1CA2KDM4EALDH1A1RAB9A | |
| SCHEMBL31304100 | 0.70 | HDAC8 (0.47) | CA1CA2KDM4EALDH1A1RAB9A | |
| SCHEMBL29151967 | 0.70 | CYP2D6 (0.44) | CA1CA2KDM4EALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL17845876 | 0.70 | KDM4E (0.51) | KDM4EALDH1A1RAB9ANPC1HPGD | |
| Hydrochloric Acid SCHEMBL637319 | 0.70 | RAB9A (0.52) | CA1CA2KDM4EALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL29754142 | 0.70 | RAB9A (0.52) | CA1CA2KDM4EALDH1A1RAB9A | |
| Ethylbenzene SCHEMBL6209262 | 0.69 | TP53 (0.64) | ALDH1A1RAB9ANPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013162-B2 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | CIBA CORPORATION (US) | 2011-09-06 | — | — | US | disclosed |
| US-7947832-B2 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | BASF SE (DE) | 2011-05-24 | — | — | US | disclosed |
| US-20090199351-A1 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | CIBA CORPORATION | 2009-08-13 | — | — | US | disclosed |
| US-20090202725-A1 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | CIBA CORPORATION | 2009-08-13 | — | — | US | disclosed |
| US-7550599-B2 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2009-06-23 | — | — | US | disclosed |
| US-20080221332-A1 | Hindered Amine salt compounds | WOOD MARVIN G | 2008-09-11 | — | — | US | disclosed |
| US-7384464-B2 | Ink jet and recording material | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2008-06-10 | — | — | US | disclosed |
| EP-1572817-B1 | INK-JET INK AND RECORDING MATERIAL | CIBA SC HOLDING AG (CH) | 2007-03-21 | — | — | EP | disclosed |
| US-20060262149-A1 | Ink jet ink and recording material | WOOD MERVIN G | 2006-11-23 | — | — | US | disclosed |
| WO-2006122888-A1 | INK JET INK AND RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-11-23 | — | — | WO | disclosed |
| WO-2002055618-A1 | INK-JET INK AND RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2002-07-18 | — | — | WO | disclosed |
| US-5509957-A | STABILIZERS FOR INK JET PRINTING | CIBA-GEIGY CORPORATION (US) | 1996-04-23 | — | — | US | disclosed |
| US-5489503-A | BIS- OR TRIS-2'HYDROXYPHENYLTRIAZINES; PHOTOGRAPHIC MATERIALS, INKS AND RECORDING MATERIALS FOR INK-JET PRINTING AND SURFACE COATINGS | CIBA-GEIGY CORP. (US) | 1996-02-06 | — | — | US | disclosed |
| US-5261953-A | CONTAINING WATER SOLUBLE STABILIZER TO IMPROVE COLORFASTNESS | CIBA-GEIGY CORPORATION (US) | 1993-11-16 | — | — | US | disclosed |
| US-5124723-A | 2-(2'-hydroxyphenyl) benzotriazoles | CIBA-GEIGY CORPORATION (US) | 1992-06-23 | — | — | US | disclosed |
| US-5096781-A | Amine salts or quaternized compounds of 2,4-diphenyl-6-/2-/hydroxyphenyl/-s-triazine derivatives; color- and washfast inks for jet printing and recording | CIBA-GEIGY CORPORATION (US) | 1992-03-17 | — | — | US | disclosed |
| US-5096489-A | 2-hydroxyphenyl-s-triazines | CIBA-GEIGY CORPORATION (US) | 1992-03-17 | — | — | US | disclosed |
| US-5089050-A | Phenol derivatives | CIBA-GEIGY CORPORATION (US) | 1992-02-18 | — | — | US | disclosed |
| US-5073448-A | Containing light stabilizers | CIBA-GEIGY CORPORATION (US) | 1991-12-17 | — | — | US | disclosed |
| US-4926190-A | EMULSIONS | CIBA-GEIGY CORPORATION (US) | 1990-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090199351-A1 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | AAAS, RAD50, IWS1 | ACHE 2103/4885CA1 4516/4885CA2 4551/4885 |
| US-20090202725-A1 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | AAAS, IWS1, HTR7 | ACHE 1980/4885CA1 4650/4885CA2 4570/4885 |
| US-20080221332-A1 | Hindered Amine salt compounds | SLC7A1, H1-0, SLC3A2 | ACHE 4546/4885CA1 125/4885CA2 247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.