Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.43 |
| ▸ | HTR3B | O95264 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819757 | 0.89 | HTR3E (0.46) | NPC1RAB9AHTR3EHTR3BHTR3A | |
| SCHEMBL919684 | 0.80 | HTR3E (0.48) | NPC1RAB9AHTR3EHTR3BHTR3A | |
| SCHEMBL6686250 | 0.77 | NPC1 (0.46) | NPC1RAB9AHTR3EHTR3BHTR3A | |
| SCHEMBL6686243 | 0.77 | NPC1 (0.46) | NPC1RAB9AHTR3EHTR3BHTR3A | |
| SCHEMBL49576 | 0.76 | LTA4H (0.38) | SMN1; SMN2MEN1KMT2ASIGMAR1ALDH1A1 | |
| SCHEMBL6541233 | 0.71 | SIGMAR1 (0.40) | NPC1RAB9ALMNASMN1; SMN2CYP1A2 | |
| SCHEMBL4857958 | 0.70 | SIGMAR1 (0.40) | NPC1RAB9ALMNASMN1; SMN2CYP1A2 | |
| SCHEMBL7794055 | 0.70 | SCN5A (0.44) | NPC1RAB9AHTR3EHTR3BHTR3A | |
| SCHEMBL96272 | 0.70 | LTA4H (0.38) | SMN1; SMN2CYP1A2MEN1KMT2ASIGMAR1 | |
| Naphthalene SCHEMBL3417714 | 0.70 | HTT (0.54) | NPC1RAB9ALMNASMN1; SMN2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4987132-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-01-22 | — | — | US | disclosed |
| EP-0279681-A2 | Saturated heterocyclic carboxamide derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1988-08-24 | — | — | EP | disclosed |