Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 2/20 | 0.37 |
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.37 |
| ▸ | HTR3B | O95264 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8750708 | 0.86 | TDP1 (0.40) | SCN5ASCN2ANOS3NOS1NOS2 | |
| SCHEMBL7793224 | 0.80 | SMN1; SMN2 (0.40) | NOS3NOS1NOS2HTR3EHTR3B | |
| SCHEMBL49576 | 0.79 | LTA4H (0.38) | NOS3NOS1NOS2SMN1; SMN2SIGMAR1 | |
| SCHEMBL7794560 | 0.77 | ALDH1A1 (0.36) | SCN5ASCN2AHTTHTR3EHTR3B | |
| SCHEMBL2094118 | 0.77 | CYP2C9 (0.53) | CYP2D6CYP2C9NPC1RAB9A | |
| SCHEMBL2097207 | 0.77 | CA12 (0.44) | NOS3NOS1NOS2HTR3EHTR3B | |
| SCHEMBL5609745 | 0.75 | ACHE (0.44) | NOS3NOS1NOS2HTR3EHTR3B | |
| SCHEMBL8178048 | 0.75 | NOS1 (0.44) | HTTNOS3NOS1NOS2HTR3E | |
| SCHEMBL8176728 | 0.75 | TSHR (0.46) | NOS3NOS1 | |
| SCHEMBL7789999 | 0.74 | HTR3E (0.43) | NOS3NOS1NOS2HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |
| US-3944670-A | Pesticidal dithiazolium salts | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1976-03-16 | — | — | US | disclosed |