Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.42 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.42 |
| ▸ | F2R | P25116 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.35 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.35 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8496044 | 0.81 | LMNA (0.48) | LMNAITGB3ITGA2B | |
| SCHEMBL7470707 | 0.81 | ITGB3 (0.41) | ITGB3ITGA2BGNAI3GNAO1GNAI1 | |
| SCHEMBL9824197 | 0.79 | GNAI3 (0.39) | ITGB3ITGA2BGNAI3GNAO1GNAI1 | |
| SCHEMBL8070099 | 0.76 | HTR4 (0.40) | ITGB3ITGA2BGNAI3GNAO1GNAI1 | |
| SCHEMBL11843874 | 0.76 | CHRM3 (0.37) | ITGB3ITGA2BGNAI3GNAO1GNAI1 | |
| SCHEMBL3597232 | 0.75 | TDP1 (0.44) | ITGB3ITGA2BGNAI3GNAO1GNAI1 | |
| SCHEMBL3059912 | 0.75 | GNAI3 (0.44) | ITGB3ITGA2BGNAI3GNAO1GNAI1 | |
| SCHEMBL8851419 | 0.75 | GNAI3 (0.46) | LMNAITGB3ITGA2BGNAI3GNAO1 | |
| SCHEMBL8851330 | 0.75 | LMNA (0.46) | LMNAITGB3ITGA2BGNAI3GNAO1 | |
| SCHEMBL28193899 | 0.74 | GNAO1 (0.39) | ITGB3ITGA2BGNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |