Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9826733 | 0.99 | KCNA3 (0.43) | KCNA3HRH3MAPTDRD3METAP2 | |
| SCHEMBL9825711 | 0.80 | HTR1A (0.43) | MAPTDRD3HTR1BDRD2 | |
| SCHEMBL9473855 | 0.73 | SIGMAR1 (0.36) | HRH3TDP1 | |
| SCHEMBL9466840 | 0.73 | SIGMAR1 (0.40) | HRH3TDP1 | |
| SCHEMBL9826279 | 0.72 | CYP2D6 (0.39) | HRH3MAPTDRD3 | |
| Hydrochloric Acid SCHEMBL9719843 | 0.70 | HTR3A (0.32) | — | |
| SCHEMBL9466779 | 0.69 | HTR2A (0.33) | DRD3DRD2HTR2AHTR7 | |
| Water SCHEMBL9825376 | 0.69 | LTA4H (0.37) | DRD3DRD2 | |
| SCHEMBL8906856 | 0.68 | DRD2 (0.46) | DRD3DRD2 | |
| SCHEMBL10576049 | 0.67 | KCNA3 (0.69) | KCNA3MAPTNR3C1TDP1HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237781-B1 | PHENYL AND HETEROCYCLIC TETRAHYDROPYRIDYL AND PIPERAZINYL ALKOXY-BENZHETEROCYCLIC COMPOUNDS AS ANTIPSYCHOTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-04-24 | — | — | EP | claimed |
| US-4704390-A | SCHIZOPHRENIA | WARNER-LAMBERT COMPANY (US) | 1987-11-03 | — | — | US | claimed |
| EP-0237781-A2 | Phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents | WARNER-LAMBERT COMPANY (US) | 1987-09-23 | — | — | EP | claimed |
| EP-0237781-B1 | PHENYL AND HETEROCYCLIC TETRAHYDROPYRIDYL AND PIPERAZINYL ALKOXY-BENZHETEROCYCLIC COMPOUNDS AS ANTIPSYCHOTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4803203-A | SCHIZOPHRENIA, NEUOLEPTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-02-07 | — | — | US | disclosed |
| US-4704390-A | SCHIZOPHRENIA | WARNER-LAMBERT COMPANY (US) | 1987-11-03 | — | — | US | disclosed |
| EP-0237781-A2 | Phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents | WARNER-LAMBERT COMPANY (US) | 1987-09-23 | — | — | EP | disclosed |