Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.56 |
| ▸ | ITGAV | P06756 | 1/20 | 0.56 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | FPR2 | P25090 | 1/20 | 0.55 |
| ▸ | CTSL | P07711 | 2/20 | 0.54 |
| ▸ | CTSB | P07858 | 2/20 | 0.54 |
| ▸ | CTSS | P25774 | 2/20 | 0.54 |
| ▸ | MME | P08473 | 1/20 | 0.54 |
| ▸ | ACE | P12821 | 1/20 | 0.54 |
| ▸ | CPA1 | P15085 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 1/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5395842 | 0.90 | GPR132 (0.62) | ITGB3ITGA2BMMEACECPA1 | |
| SCHEMBL7044293 | 0.88 | ATM (0.67) | ALDH1A1ALOX15ITGB3ITGA2BATM | |
| SCHEMBL9716776 | 0.88 | ATM (0.67) | ALDH1A1ALOX15ITGB3ITGA2BATM | |
| SCHEMBL7044299 | 0.88 | ATM (0.67) | ALDH1A1ALOX15ITGB3ITGA2BATM | |
| SCHEMBL7039089 | 0.88 | ATM (0.67) | ALDH1A1ALOX15ITGB3ITGA2BATM | |
| SCHEMBL9716778 | 0.88 | ATM (0.67) | ALDH1A1ALOX15ITGB3ITGA2BATM | |
| SCHEMBL13536744 | 0.85 | CTSK (0.62) | ALDH1A1ALOX15ITGB3ITGAVITGA2B | |
| SCHEMBL7438617 | 0.85 | TRPM8 (0.53) | ALDH1A1ALOX15ATMNPC1RAB9A | |
| SCHEMBL5502788 | 0.85 | FPR2 (0.52) | ALDH1A1ALOX15ITGB3ITGAVITGA2B | |
| SCHEMBL9825830 | 0.85 | TYR (0.58) | ALDH1A1ALOX15ITGB3ITGAVITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237082-B1 | 3,5-DISUBSTITUTED 4,5-DIHYDROISOXAZOLES AS TRANSGLUTAMINASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| US-4929630-A | SKIN DISORDERS, ACNE, 4,5-DIHYDROISOOXAZOLE PEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1990-05-29 | — | — | US | disclosed |
| US-4912120-A | Containing amine and amide substitution | SYNTEX (U.S.A.) INC. (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |