Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.63 |
| ▸ | CA1 | P00915 | 3/20 | 0.63 |
| ▸ | CA2 | P00918 | 3/20 | 0.63 |
| ▸ | CA7 | P43166 | 3/20 | 0.63 |
| ▸ | CA9 | Q16790 | 3/20 | 0.63 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.63 |
| ▸ | P4HB | P07237 | 1/20 | 0.58 |
| ▸ | XDH | P47989 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | STS | P08842 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2339850 | 0.91 | TSHR (0.61) | CA12CA1CA2CA7CA9 | |
| SCHEMBL2892627 | 0.89 | TSHR (0.61) | CA12CA1CA2CA7CA9 | |
| SCHEMBL10420733 | 0.88 | P4HB (0.60) | CA12CA1CA2CA7CA9 | |
| SCHEMBL5733350 | 0.87 | L3MBTL1 (0.69) | HTTHPGDATMTDP1L3MBTL1 | |
| SCHEMBL9828698 | 0.87 | LOXL2 (0.54) | CA12CA1CA2CA7CA9 | |
| SCHEMBL10506033 | 0.86 | TDP1 (0.63) | CA12CA1CA2CA7CA9 | |
| SCHEMBL7907765 | 0.86 | CA12 (0.58) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3467966 | 0.85 | CA1 (0.87) | CA12CA1CA2CA7CA9 | |
| SCHEMBL698836 | 0.85 | LMNA (0.71) | LMNAHTTMAPTESR1ESR2 | |
| SCHEMBL10395127 | 0.85 | LMNA (0.71) | LMNAHTTMAPTESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5051427-A | Antiinflammatory agents and antiallergens | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-09-24 | — | — | US | disclosed |
| EP-0395697-A4 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1991-03-13 | — | — | EP | disclosed |
| EP-0395697-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4 | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1990-11-07 | — | — | EP | disclosed |
| US-4920133-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| WO-1989004303-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-05-18 | — | — | WO | disclosed |