Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CA9 | Q16790 | 4/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829941 | 0.92 | ALDH1A1 (0.42) | ALDH1A1KDM4EMEN1KMT2ACYP3A4 | |
| SCHEMBL9829851 | 0.87 | HSD17B10 (0.51) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9832327 | 0.86 | ALDH1A1 (0.50) | ALDH1A1KDM4EMEN1KMT2ATDP1 | |
| SCHEMBL10407429 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KDM4EMEN1KMT2ACA1 | |
| SCHEMBL9831173 | 0.84 | ACHE (0.51) | MEN1KMT2ABCHEACHE | |
| SCHEMBL9829521 | 0.81 | ALDH1A1 (0.50) | ALDH1A1KDM4EMEN1KMT2ACYP3A4 | |
| SCHEMBL9832835 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9830890 | 0.79 | SMN1; SMN2 (0.43) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9831156 | 0.79 | TSHR (0.45) | ALDH1A1KDM4ECYP3A4 | |
| SCHEMBL9832189 | 0.78 | ALDH1A1 (0.49) | ALDH1A1KDM4EMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |