Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831726 | 0.93 | KEAP1 (0.44) | PPARGLMNAL3MBTL1ALDH1A1GAA | |
| SCHEMBL9833033 | 0.90 | ALDH1A1 (0.46) | PPARGLMNAALDH1A1GAANPC1 | |
| SCHEMBL9830077 | 0.83 | TSHR (0.43) | PPARGLMNAALDH1A1GAANPC1 | |
| SCHEMBL15744661 | 0.81 | PTPN1 (0.48) | PPARGLMNAL3MBTL1ALDH1A1GAA | |
| SCHEMBL9832767 | 0.80 | PPARG (0.62) | PPARGLMNAL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL9831443 | 0.80 | PPARG (0.50) | PPARGLMNAALDH1A1KDM4EMEN1 | |
| SCHEMBL9832189 | 0.78 | ALDH1A1 (0.49) | LMNAL3MBTL1ALDH1A1TSHRPOLB | |
| SCHEMBL9830898 | 0.78 | ALDH1A1 (0.55) | PPARGALDH1A1GAAHPGDKDM4E | |
| SCHEMBL9831770 | 0.78 | PPARG (0.50) | PPARGLMNAALDH1A1GAANPC1 | |
| SCHEMBL9830282 | 0.78 | ALDH1A1 (0.42) | PPARGLMNAL3MBTL1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |