Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831046 | 0.92 | NLRP3 (0.43) | SMN1; SMN2NLRP3MAPTALDH1A1POLB | |
| SCHEMBL9830888 | 0.86 | SMN1; SMN2 (0.50) | SMN1; SMN2NLRP3MAPTALDH1A1MEN1 | |
| SCHEMBL9831206 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2MAPTALDH1A1POLBKMT2A | |
| SCHEMBL9830592 | 0.81 | KMT2A (0.44) | SMN1; SMN2ALDH1A1KMT2AALOX5LTA4H | |
| SCHEMBL9829350 | 0.79 | ALOX5 (0.50) | SMN1; SMN2ALDH1A1POLBKMT2AHSD17B10 | |
| SCHEMBL9831033 | 0.79 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9829851 | 0.78 | HSD17B10 (0.51) | ALDH1A1POLBMEN1KMT2ATSHR | |
| SCHEMBL9830346 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2NLRP3MAPTALDH1A1MEN1 | |
| SCHEMBL9831173 | 0.78 | ACHE (0.51) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9832327 | 0.77 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |