Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.59 |
| ▸ | HTR1A | P08908 | 9/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4834380 | 0.80 | SLC6A4 (0.50) | SLC6A4HTR1A | |
| SCHEMBL9830738 | 0.80 | HTR6 (0.67) | SLC6A4HTR6 | |
| SCHEMBL8656583 | 0.79 | SLC6A4 (0.48) | SLC6A4HTR1A | |
| SCHEMBL27842093 | 0.75 | SLC6A4 (0.64) | SLC6A4HTR6 | |
| SCHEMBL4834742 | 0.74 | SLC6A4 (0.50) | SLC6A4HTR1A | |
| SCHEMBL24243716 | 0.74 | SLC6A4 (0.70) | SLC6A4HTR1A | |
| SCHEMBL1122134 | 0.73 | SLC6A4 (0.85) | SLC6A4HTR1AHTR6 | |
| SCHEMBL12204700 | 0.71 | TRPM8 (0.66) | SLC6A4HTR6 | |
| SCHEMBL9264529 | 0.71 | SLC6A4 (0.66) | SLC6A4HTR1A | |
| SCHEMBL3103741 | 0.71 | SLC6A4 (0.73) | SLC6A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432282-B2 | Pyridinalkyl-aminoalkyl-IH-indole derivatives having an inhibitory action on 5-HT and serotonin reuptake as antidepressants and anxiolytics | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-10-07 | — | — | US | claimed |
| EP-1562596-B1 | DERIVATIVES OF PYRIDINALKYL-AMONOALKYL-1H-INDOLE INHIBITING RECEPTORS 5-HT AND RECAPTURE OF SEROTONIN WHICH CAN BE USED AS ANTIDEPRESSANT AND ANXIOLITIC | MERCK PATENT GMBH (DE) | 2006-08-30 | — | — | EP | claimed |
| US-20060063811-A1 | PYRIDINALKYL-AMINOALKYL-IH-INDOLE DERIVATIVES HAVING AN INHIBITORY ACTION ON 5-HT AND SEROTONIN REUPTAKE AS ANTIDEPRESSANTS AND ANXIOLYTICS | MERCK PATENT GMBH (DE) | 2006-03-23 | — | — | US | claimed |
| EP-1562596-A1 | DERIVATIVES OF PYRIDINALKYL-AMONOALKYL-1H-INDOLE INHIBITING RECEPTORS 5-HT AND RECAPTURE OF SEROTONIN WHICH CAN BE USED AS ANTIDEPRESSANT AND ANXIOLITIC | MERCK PATENT GmbH (DE) | 2005-08-17 | — | — | EP | claimed |
| WO-2004047840-A1 | DERIVATIVES OF PYRIDINALKYL-AMONOALKYL-1H-INDOLE INHIBITING RECEPTORS 5-HT AND RECAPTURE OF SEROTONIN WHICH CAN BE USED AS ANTIDEPRESSANT AND ANXIOLITIC | MERCK PATENT GMBH (DE) | 2004-06-10 | — | — | WO | claimed |
| US-7432282-B2 | Pyridinalkyl-aminoalkyl-IH-indole derivatives having an inhibitory action on 5-HT and serotonin reuptake as antidepressants and anxiolytics | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-10-07 | — | — | US | disclosed |
| EP-1562596-B1 | DERIVATIVES OF PYRIDINALKYL-AMONOALKYL-1H-INDOLE INHIBITING RECEPTORS 5-HT AND RECAPTURE OF SEROTONIN WHICH CAN BE USED AS ANTIDEPRESSANT AND ANXIOLITIC | MERCK PATENT GMBH (DE) | 2006-08-30 | — | — | EP | disclosed |
| US-20060063811-A1 | PYRIDINALKYL-AMINOALKYL-IH-INDOLE DERIVATIVES HAVING AN INHIBITORY ACTION ON 5-HT AND SEROTONIN REUPTAKE AS ANTIDEPRESSANTS AND ANXIOLYTICS | MERCK PATENT GMBH (DE) | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063811-A1 | PYRIDINALKYL-AMINOALKYL-IH-INDOLE DERIVATIVES HAVING AN INHIBITORY ACTION ON 5-HT AND SEROTONIN REUPTAKE AS ANTIDEPRESSANTS AND ANXIOLYTICS | HTR1A, HTR1D, HTR1E | SLC6A4 22/4885HTR1A 1/4885HTR6 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.