Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11530002 | 0.79 | ADRB1 (0.67) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL7292849 | 0.79 | NOTUM (0.38) | IP6K1ALDH1A1ADRB1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL11530582 | 0.78 | ADRB1 (0.64) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL9829419 | 0.77 | ADRB1 (0.64) | IP6K1ALDH1A1ADRB1POLBCHRM2 | |
| SCHEMBL2273801 | 0.77 | ADRB1 (0.58) | IP6K1ALDH1A1ADRB1POLBCHRM2 | |
| SCHEMBL9830834 | 0.76 | ADRB1 (0.68) | ALDH1A1ADRB1MAPTGFERLMNA | |
| SCHEMBL2806281 | 0.76 | ALDH1A3 (0.49) | IP6K1ALDH1A1ADRB1CHRM2CHRM4 | |
| SCHEMBL11837825 | 0.75 | ALDH1A1 (0.50) | ALDH1A1POLBMAPTLMNASMN1; SMN2 | |
| SCHEMBL7715055 | 0.75 | ADRB1 (0.66) | ALDH1A1ADRB1POLBMAPTLMNA | |
| SCHEMBL11528445 | 0.74 | CHRNA7 (0.53) | ALDH1A1MAPTGFERLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |