Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21221367 | 0.84 | MAOB (0.47) | MAOB | |
| SCHEMBL9829920 | 0.82 | MAOB (0.50) | ALDH1A1KMT2AMAOBKCNQ2 | |
| SCHEMBL10408425 | 0.81 | RAD51 (0.40) | ALDH1A1KMT2AMAOB | |
| SCHEMBL17893675 | 0.77 | ALDH1A1 (0.38) | ALDH1A1KMT2AKAT2BIP6K1CHRM2 | |
| SCHEMBL9833165 | 0.76 | CHRM2 (0.48) | KMT2ACHRM2 | |
| SCHEMBL9831474 | 0.74 | ALOX5 (0.33) | KMT2AKCNQ2 | |
| SCHEMBL10407582 | 0.74 | ALDH1A1 (0.46) | ALDH1A1KMT2AKCNQ2 | |
| SCHEMBL568685 | 0.74 | MAOB (0.49) | ALDH1A1MAOB | |
| SCHEMBL1410628 | 0.74 | ADRB1 (0.51) | ALDH1A1KMT2ACES2 | |
| SCHEMBL9830345 | 0.73 | NR1H2 (0.41) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |