Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7486606 | 0.91 | MAPT (0.56) | MAPTLMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9831285 | 0.88 | KDM4E (0.49) | MAPTLMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL8562906 | 0.85 | LMNA (0.48) | MAPTLMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL8382286 | 0.80 | MAPT (0.67) | MAPTLMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL8564312 | 0.80 | MAPT (0.56) | MAPTLMNAALDH1A1KMT2ATP53 | |
| SCHEMBL7492848 | 0.78 | TSHR (0.54) | MAPTLMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL9830402 | 0.77 | MAPT (0.63) | MAPTLMNAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9828629 | 0.76 | ADRB1 (0.51) | MAPTALDH1A1TSHR | |
| SCHEMBL9829333 | 0.76 | POLB (0.53) | MAPTLMNAALDH1A1HSD17B10KMT2A | |
| SCHEMBL9833027 | 0.75 | MAPT (0.50) | MAPTLMNAALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |