SCHEMBL8564312

SCHEMBL8564312

COc1ccccc1N1CCC(=O)C1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.56
DRD2 P14416 3/20 0.56
DRD3 P35462 2/20 0.56
ALDH1A1 P00352 2/20 0.56
HPGD P15428 1/20 0.56
CYP2C19 P33261 2/20 0.54
HTR3E A5X5Y0 1/20 0.54
HTR3B O95264 1/20 0.54
ADRB1 P08588 1/20 0.54
HTR3A P46098 1/20 0.54
HTR6 P50406 1/20 0.54
HTR3D Q70Z44 1/20 0.54
HTR3C Q8WXA8 1/20 0.54
SIGMAR1 Q99720 1/20 0.54
LMNA P02545 1/20 0.53
AKR1C3 P42330 1/20 0.50
MEN1 O00255 1/20 0.50
CYP1A2 P05177 1/20 0.50
HTR1A P08908 1/20 0.50
CYP2C9 P11712 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1681827 0.90 DRD2 (0.64) MAPTDRD2DRD3ALDH1A1HPGD
Ethylene SCHEMBL7715815 0.87 DRD2 (0.60) MAPTDRD2DRD3ALDH1A1HPGD
SCHEMBL29138524 0.86 MAPT (0.68) MAPTDRD2DRD3ALDH1A1HPGD
SCHEMBL9832439 0.86 KDM4E (0.44) MAPTDRD2DRD3ALDH1A1HPGD
SCHEMBL7497866 0.81 ACHE (0.46) MAPTDRD2DRD3ALDH1A1HPGD
SCHEMBL27946081 0.80 MAPT (0.75) MAPTDRD2DRD3ALDH1A1HPGD
SCHEMBL8562906 0.80 LMNA (0.48) MAPTALDH1A1LMNAHTR1AKMT2A
SCHEMBL9831285 0.80 KDM4E (0.49) MAPTALDH1A1LMNAMEN1HTR1A
SCHEMBL9832152 0.80 MAPT (0.57) MAPTALDH1A1LMNAKMT2ATP53
SCHEMBL9831929 0.77 ALDH1A1 (0.53) MAPTALDH1A1HPGDADRB1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0853622-A1 PROCESS FOR PREPARING 1-ARYL-4-OXOPYRROLO 3,2-c]QUINOLINE DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1998-07-22 EP disclosed
WO-1997044342-A1 PROCESS FOR PREPARING 1-ARYL-4-OXOPYRROLO[3,2-c]QUINOLINE DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1997-11-27 WO disclosed
EP-0449989-A1 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES Sloan-Kettering Institute For Cancer Research (US) 1991-10-09 EP disclosed
WO-1990007496-A1 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1990-07-12 WO disclosed
US-4925939-A 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1990-05-15 US disclosed