Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | ERN1 | O75460 | 4/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833083 | 0.90 | OPRM1 (0.40) | MAPTKDM4EGAAOPRM1OPRD1 | |
| SCHEMBL10423292 | 0.81 | KDM4E (0.41) | MAPTKDM4EGAAALOX5PTGS1 | |
| SCHEMBL9831796 | 0.78 | NPC1 (0.35) | MAPTESR1ALDH1A1KMT2ALMNA | |
| SCHEMBL9834177 | 0.77 | MAPT (0.42) | MAPTKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL9831654 | 0.77 | MAPT (0.41) | MAPTKDM4EGAAALOX5PTGS1 | |
| SCHEMBL9834283 | 0.75 | OPRM1 (0.58) | MAPTKDM4EGAAALOX5PTGS1 | |
| SCHEMBL9831867 | 0.73 | OPRM1 (0.40) | MAPTKDM4EGAAOPRM1OPRD1 | |
| SCHEMBL9832757 | 0.73 | TUBB4A (0.38) | MAPTKDM4EGAAESR1MEN1 | |
| SCHEMBL9799232 | 0.71 | OPRM1 (0.40) | MAPTPTGS2OPRM1OPRD1NR1I2 | |
| SCHEMBL9799267 | 0.71 | CYP3A4 (0.46) | KDM4EOPRM1CHRM2ADRA2BSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297782-B1 | A THIOPHENE DERIVATIVE AND PROCESS FOR PREPARING THE SAME | TANABE SEIYAKU CO., LTD. (JP) | 1991-05-22 | — | — | EP | disclosed |
| US-4857543-A | TREATMENT OF GASTROINTESTINAL DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0297782-A1 | A thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1989-01-04 | — | — | EP | disclosed |