Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9799232 | 0.89 | OPRM1 (0.40) | CYP3A4CYP2D6CYP1A2AOC3SMN1; SMN2 | |
| SCHEMBL10423292 | 0.88 | KDM4E (0.41) | KDM4ECHRM2ADRA2BSLC6A4OPRM1 | |
| SCHEMBL9830311 | 0.82 | CYP1A2 (0.40) | CYP3A4CYP2D6CYP1A2BLMPMP22 | |
| SCHEMBL9799293 | 0.80 | FDPS (0.38) | AOC3SMN1; SMN2KCNH2 | |
| SCHEMBL9799289 | 0.76 | OPRM1 (0.43) | CYP3A4CYP2D6CYP1A2AOC3KDM4E | |
| SCHEMBL9832363 | 0.73 | OPRM1 (0.43) | CYP3A4CYP2D6CYP1A2AOC3SMN1; SMN2 | |
| SCHEMBL9831867 | 0.73 | OPRM1 (0.40) | CYP3A4CYP2D6CYP1A2KDM4ESMN1; SMN2 | |
| SCHEMBL9831654 | 0.72 | MAPT (0.41) | CYP3A4KDM4ESMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL9832269 | 0.71 | MAPT (0.36) | CYP3A4KDM4ESMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL16382429 | 0.68 | ATM (0.58) | CYP3A4CYP2D6CYP1A2BLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298703-B1 | A THIOPHENE DERIVATIVE AND PROCESS FOR PREPARING THE SAME | TANABE SEIYAKU CO., LTD. (JP) | 1991-03-06 | — | — | EP | disclosed |
| US-4946862-A | Thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1990-08-07 | — | — | US | disclosed |
| EP-0298703-A1 | A thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1989-01-11 | — | — | EP | disclosed |