Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485829 | 0.82 | LMNA (0.50) | MEN1KMT2ATDP1POLBGAA | |
| SCHEMBL7306147 | 0.79 | MAPT (0.50) | MEN1KMT2ATDP1POLBLMNA | |
| SCHEMBL7299383 | 0.79 | ALDH1A1 (0.43) | MEN1KMT2ATDP1KDM4CLMNA | |
| SCHEMBL7435538 | 0.72 | GRM5 (0.38) | MAPTALDH1A1HSD17B10SMN1; SMN2GRM5 | |
| SCHEMBL1544475 | 0.68 | HSD17B10 (0.71) | TDP1POLBBCHELMNAALDH1A1 | |
| SCHEMBL7306066 | 0.67 | KDM4E (0.45) | TDP1POLBLMNAMAPTALDH1A1 | |
| SCHEMBL7297002 | 0.67 | TDP1 (0.45) | TDP1POLBALDH1A1ALOX15HSD17B10 | |
| SCHEMBL11590519 | 0.67 | NR1H3 (0.69) | MEN1KMT2APOLBKDM4CGAA | |
| SCHEMBL1544493 | 0.65 | SMN1; SMN2 (0.49) | MEN1KMT2APOLBGAALMNA | |
| SCHEMBL10988191 | 0.65 | MEN1 (0.46) | MEN1KMT2AKDM4CGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226755-B1 | 5-HETEROCYCLIC-3H-1,2,4-TRIAZOLE-3-THIONES AND THEIR USE AS ANTIDEPRESSANTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-08-14 | — | — | EP | claimed |
| US-4952593-A | 5-heterocyclic-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-08-28 | — | — | US | claimed |
| EP-0226755-A1 | 5-Heterocyclic-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-07-01 | — | — | EP | claimed |
| US-4952593-A | 5-heterocyclic-2,4-dialkyl-3H-1,2,4-triazole-3-thiones and their use as antidepressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-08-28 | — | — | US | disclosed |