Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | DRD3 | P35462 | 6/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.49 |
| ▸ | DRD4 | P21917 | 4/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | HTR7 | P34969 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833997 | 0.90 | ADRA2B (0.51) | DRD2DRD3CHRM2CHRM1CHRM3 | |
| SCHEMBL19656193 | 0.86 | CHRM2 (0.54) | DRD2DRD3CHRM2CHRM1CHRM3 | |
| SCHEMBL8998982 | 0.82 | ADRA2B (0.39) | DRD2DRD3CHRM2CHRM1CHRM3 | |
| SCHEMBL18092717 | 0.81 | CHRM2 (0.50) | DRD2DRD3CHRM2CHRM1CHRM3 | |
| SCHEMBL7708386 | 0.81 | HTR7 (0.51) | DRD2DRD3CHRM2CHRM1CHRM3 | |
| SCHEMBL7476444 | 0.80 | DRD2 (0.63) | DRD2DRD3CHRM2CHRM1CHRM3 | |
| SCHEMBL344854 | 0.79 | ALDH1A1 (0.54) | DRD2DRD3CHRM2CHRM1CHRM3 | |
| SCHEMBL590887 | 0.79 | ALDH1A1 (0.54) | DRD2DRD3CHRM2CHRM1CHRM3 | |
| SCHEMBL27474717 | 0.79 | ALDH1A1 (0.54) | DRD2DRD3CHRM2CHRM1CHRM3 | |
| SCHEMBL29643502 | 0.79 | ALDH1A1 (0.54) | DRD2DRD3CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208510-B1 | 1-SUBSTITUTED OXINDOLE-3-CARBOXAMINES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |