Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B | P18089 | 4/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833912 | 0.90 | DRD2 (0.49) | ADRA2BADRA2CADRA2ALMNAALDH1A1 | |
| SCHEMBL8998982 | 0.85 | ADRA2B (0.39) | ADRA2BADRA2CADRA2ALMNAALDH1A1 | |
| SCHEMBL14281158 | 0.85 | ADRA2B (0.57) | ADRA2BADRA2CADRA2ALMNAALDH1A1 | |
| SCHEMBL8240109 | 0.79 | HTR7 (0.57) | ADRA2BADRA2CADRA2AHTR7CHRM2 | |
| SCHEMBL22018905 | 0.77 | HTR2A (0.61) | ADRA2BADRA2CADRA2ALMNAALDH1A1 | |
| SCHEMBL8999008 | 0.75 | MAOA (0.40) | ADRA2BADRA2CADRA2ALMNAALDH1A1 | |
| SCHEMBL19656193 | 0.74 | CHRM2 (0.54) | ADRA2BADRA2CADRA2ALMNAALDH1A1 | |
| SCHEMBL7708386 | 0.73 | HTR7 (0.51) | ADRA2BADRA2CADRA2ALMNAALDH1A1 | |
| SCHEMBL9095440 | 0.72 | HDAC3 (0.44) | ADRA2BADRA2CADRA2ALMNAALDH1A1 | |
| SCHEMBL6249842 | 0.72 | ADRA2C (0.52) | ADRA2BADRA2CADRA2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208510-B1 | 1-SUBSTITUTED OXINDOLE-3-CARBOXAMINES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |