SCHEMBL9837428

SCHEMBL9837428

C=C(C)C(OC(=O)Nc1cc(OC(C)(C)C)c(Cl)cc1Cl)C(=O)OC

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.37
MAPT P10636 4/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
ALDH1A1 P00352 6/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
POLB P06746 2/20 0.36
TSHR P16473 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
HTT P42858 1/20 0.34
KDM4E B2RXH2 3/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
HPGD P15428 2/20 0.33
NPY1R P25929 1/20 0.33
NPY2R P49146 1/20 0.33
RAB9A P51151 1/20 0.33
RECQL P46063 1/20 0.32
GAA P10253 2/20 0.32
MAPK1 P28482 1/20 0.32
RORC P51449 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9834362 0.90 LMNA (0.34) LMNAMAPTMEN1KMT2AALDH1A1
SCHEMBL9837587 0.89 LMNA (0.47) LMNAMAPTMEN1KMT2AALDH1A1
SCHEMBL9835450 0.79 NPSR1 (0.43) LMNAMAPTMEN1KMT2AALDH1A1
SCHEMBL9836734 0.78 LMNA (0.36) LMNAMAPTALDH1A1L3MBTL1POLB
SCHEMBL9836716 0.78 RORC (0.41) LMNAMAPTMEN1KMT2AALDH1A1
SCHEMBL9836882 0.78 EPHX1 (0.46) LMNAMAPTMEN1KMT2AALDH1A1
SCHEMBL9834529 0.78 USP2 (0.50) LMNAMAPTMEN1KMT2AALDH1A1
SCHEMBL9837437 0.78 LMNA (0.33) LMNAMAPTMEN1KMT2AALDH1A1
SCHEMBL8998058 0.77 LMNA (0.34) LMNAMAPTKMT2AALDH1A1L3MBTL1
SCHEMBL9427372 0.76 LMNA (0.34) LMNAMAPTKMT2AALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0241559-B1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-10-30 EP disclosed
US-4983751-A Chemical intermediates SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-01-08 US disclosed
US-4818272-A NONPHYTOTOXICITY FOR CROPS HELICAL STREAMS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1989-04-04 US disclosed
EP-0241559-A1 OXAZOLIDINEDIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND HERBICIDES CONTAINING THE SAME SAGAMI CHEMICAL RESEARCH CENTER (JP) 1987-10-21 EP disclosed