SCHEMBL9836670

SCHEMBL9836670

O=c1c2ccccc2oc2c(Br)cc(O)cc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 9/20 0.59
ESR2 Q92731 4/20 0.59
PTGS2 P35354 1/20 0.53
ESR1 P03372 1/20 0.52
KDM4E B2RXH2 1/20 0.52
ALDH1A1 P00352 1/20 0.52
GLA P06280 1/20 0.52
CYP3A4 P08684 1/20 0.52
MAPT P10636 1/20 0.52
HPGD P15428 1/20 0.52
PGAM1 P18669 1/20 0.52
CASP1 P29466 1/20 0.52
CASP7 P55210 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
HSD17B10 Q99714 1/20 0.52
MGAM O43451 1/20 0.51
GAA P10253 1/20 0.51
SI P14410 1/20 0.51
MGAM2 Q2M2H8 1/20 0.51
KDM5A P29375 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5951377 0.87 ESR2 (0.50) MAOAESR2PTGS2ESR1KDM4E
SCHEMBL29164297 0.84 MAOA (0.55) MAOAPTGS2KDM4EALDH1A1GLA
SCHEMBL9836115 0.80 ESR2 (0.51) MAOAESR2ESR1MGAMGAA
SCHEMBL3267918 0.78 MAOA (0.64) MAOAPTGS2KDM4EALDH1A1GLA
SCHEMBL17820117 0.77 MAOA (0.62) MAOAESR2ESR1KDM4EALDH1A1
SCHEMBL30599042 0.75 MAOA (1.00) MAOAESR2ESR1KDM4EALDH1A1
Xanthone SCHEMBL29025600 0.75 MAOA (1.00) MAOAESR2ESR1KDM4EALDH1A1
SCHEMBL1675981 0.75 MAOA (1.00) MAOAESR2ESR1KDM4EALDH1A1
SCHEMBL9835701 0.74 LMNA (0.57) MAOAKDM4EALDH1A1HPGDSMN1; SMN2
SCHEMBL7232063 0.74 PTGS2 (0.69) MAOAPTGS2KDM4EALDH1A1GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0175376-B1 XANTHONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME Chugai Seiyaku Kabushiki Kaisha (JP) 1991-04-03 EP disclosed
US-4816479-A HYPOTENSIVE AGENTS, DIURETICS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1989-03-28 US disclosed
US-4661607-A ANTIEDEMIC AGENTS, HYPOTENSIVE AGENTS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1987-04-28 US disclosed
EP-0175376-A2 Xanthone derivatives and process for producing the same Chugai Seiyaku Kabushiki Kaisha (JP) 1986-03-26 EP disclosed