Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14479768 | 0.84 | NR1H2 (0.37) | PGRKMT2A | |
| SCHEMBL9834685 | 0.80 | PGR (0.51) | TGFBR1PGRMAPTKMT2A | |
| SCHEMBL14620062 | 0.78 | COMT (0.40) | RAB9AMAPTKMT2AHSP90AA1MGLL | |
| SCHEMBL5070001 | 0.78 | NR1H2 (0.52) | MAPTMGLL | |
| SCHEMBL9836026 | 0.78 | PTGS2 (0.50) | RAB9AACHEMAPTKMT2AMGLL | |
| SCHEMBL12725181 | 0.76 | NR1H2 (0.50) | MAPTMGLL | |
| SCHEMBL12725183 | 0.76 | PTGS2 (0.49) | ACHEMAPTKMT2AMGLL | |
| SCHEMBL9836649 | 0.76 | PGR (0.46) | CLK4TGFBR1PGR | |
| SCHEMBL14620069 | 0.74 | NR1H2 (0.45) | MAPT | |
| SCHEMBL8439734 | 0.71 | L3MBTL1 (0.39) | ACHENOTUMKMT2ATDP2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0133156-B1 | 1,4-DIKETOPYRROLO-(3,4-C) PYRROLES | CIBA-GEIGY AG (CH) | 1991-07-10 | — | — | EP | disclosed |
| US-4666455-A | Compositions pigmented with N-substituted 1,4-diketopyrrolo-[3,4-c]-pyrroles | CIBA-GEIGY CORPORATION (US) | 1987-05-19 | — | — | US | disclosed |
| US-4585878-A | N-substituted 1,4-diketopyrrolo-[3,4-c]-pyrroles | CIBA-GEIGY CORPORATION (US) | 1986-04-29 | — | — | US | disclosed |
| EP-0133156-A2 | 1,4-Diketopyrrolo-(3,4-c) pyrroles | CIBA-GEIGY AG (CH) | 1985-02-13 | — | — | EP | disclosed |