Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 9/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.39 |
| ▸ | IL2 | P60568 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9842993 | 0.85 | IL2 (0.48) | HDAC6TRPV1IL2 | |
| SCHEMBL9843028 | 0.85 | CNR1 (0.51) | HDAC6CHEK1 | |
| SCHEMBL9842960 | 0.85 | KDR (0.42) | IL2 | |
| SCHEMBL9842919 | 0.82 | CYP1A2 (0.42) | IL2 | |
| SCHEMBL9842940 | 0.82 | CNR1 (0.53) | IL2 | |
| SCHEMBL9842938 | 0.81 | IL2 (0.39) | IL2 | |
| SCHEMBL9842822 | 0.81 | NPC1 (0.43) | IL2 | |
| SCHEMBL9842888 | 0.80 | TRPV1 (0.60) | ABL1TRPV1OPRM1KCNH2 | |
| SCHEMBL9842991 | 0.80 | CNR1 (0.54) | HDAC6TRPV1IL2 | |
| SCHEMBL9843027 | 0.78 | CNR1 (0.52) | HDAC6IL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0440503-A1 | 4-Isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-08-07 | — | — | EP | disclosed |