Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9728246 | 0.79 | CHRNB2 (0.40) | CHRNB2CHRNA4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9843230 | 0.74 | RIPK1 (0.49) | RIPK1CHRNB2CHRNA4LMNANAMPT | |
| SCHEMBL7662016 | 0.73 | CHRNB2 (0.54) | RIPK1CHRNB2CHRNA4LMNANAMPT | |
| SCHEMBL7665299 | 0.72 | LMNA (0.48) | RIPK1CHRNB2CHRNA4LMNANAMPT | |
| SCHEMBL9718704 | 0.72 | RIPK1 (0.47) | RIPK1CHRNB2CHRNA4LMNANAMPT | |
| SCHEMBL7660306 | 0.72 | RIPK1 (0.47) | RIPK1CHRNB2CHRNA4LMNANAMPT | |
| SCHEMBL7669212 | 0.72 | RIPK1 (0.47) | RIPK1CHRNB2CHRNA4LMNANAMPT | |
| SCHEMBL27717225 | 0.72 | RIPK1 (0.49) | RIPK1CHRNB2CHRNA4LMNANAMPT | |
| SCHEMBL8560242 | 0.72 | RIPK1 (0.46) | RIPK1CHRNB2CHRNA4LMNANAMPT | |
| SCHEMBL7686987 | 0.71 | RIPK1 (0.48) | RIPK1CHRNB2CHRNA4LMNANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1050186-A | Guanidine derivative | CIBA GEIGY AG (CH) | 1991-03-27 | — | — | CN | claimed |
| EP-0418199-A2 | Guanidine derivatives | CIBA-GEIGY AG (CH) | 1991-03-20 | — | — | EP | claimed |
| CN-1050186-A | Guanidine derivative | CIBA GEIGY AG (CH) | 1991-03-27 | — | — | CN | disclosed |
| EP-0418199-A2 | Guanidine derivatives | CIBA-GEIGY AG (CH) | 1991-03-20 | — | — | EP | disclosed |