SCHEMBL4647513

SCHEMBL4647513

[CH2]CC(=O)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.33
HIF1A Q16665 1/20 0.33
MAPT P10636 2/20 0.33
ABL1 P00519 1/20 0.32
ADRB2 P07550 2/20 0.32
ADRB1 P08588 2/20 0.32
ADRB3 P13945 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
TSHR P16473 2/20 0.32
ALDH1A1 P00352 1/20 0.32
HSD17B10 Q99714 1/20 0.32
HTR1A P08908 1/20 0.31
CYP2D6 P10635 1/20 0.31
SCN1A P35498 1/20 0.31
SLC6A3 Q01959 1/20 0.31
SCN5A Q14524 1/20 0.31
SCN2A Q99250 1/20 0.31
SCN3A Q9NY46 1/20 0.31
KMT2A Q03164 2/20 0.31
CYP3A4 P08684 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4643575 0.87 CYP2C19 (0.32) CYP2C19HIF1AMAPTABL1TDP1
SCHEMBL6072557 0.86 ABL1 (0.35) CYP2C19HIF1AMAPTABL1TSHR
SCHEMBL6546547 0.86 CYP2C19 (0.35) CYP2C19HIF1AMAPTABL1TDP1
SCHEMBL4644895 0.85 TSHR (0.35) CYP2C19HIF1AMAPTABL1ADRB2
SCHEMBL9845210 0.85 ELANE (0.39) CYP2C19HIF1AMAPTABL1ALDH1A1
SCHEMBL4647018 0.84 PRSS1 (0.34) CYP2C19HIF1AABL1ADRB2ADRB1
SCHEMBL6545076 0.83 KDM4E (0.36) CYP2C19HIF1AMAPTABL1ADRB2
SCHEMBL4647641 0.83 ALDH1A1 (0.36) CYP2C19HIF1AMAPTABL1TDP1
SCHEMBL6072563 0.83 CYP2C19 (0.37) CYP2C19HIF1AMAPTABL1TSHR
SCHEMBL6656947 0.82 NR4A2 (0.38) CYP2C19HIF1AALDH1A1CYP2D6SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1487928-B1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2008-08-13 EP disclosed
EP-1487928-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT Jotun AS (NO) 2004-12-22 EP disclosed
WO-2003080747-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2003-10-02 WO disclosed