Fluoride

Fluoride

SCHEMBL984644

F.F.F.F.F.O=[N+]([O-])c1ccccc1[S]

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.52
TDP1 Q9NUW8 5/20 0.50
ALDH1A1 P00352 9/20 0.48
KMT2A Q03164 2/20 0.48
MEN1 O00255 1/20 0.48
GPR35 Q9HC97 1/20 0.48
TSHR P16473 2/20 0.47
NPC1 O15118 1/20 0.45
RECQL P46063 1/20 0.45
RAB9A P51151 1/20 0.45
MAPK1 P28482 1/20 0.44
CASP7 P55210 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.43
HPGD P15428 1/20 0.42
PLAU P00749 1/20 0.42
PTPRC P08575 1/20 0.42
S100A4 P26447 1/20 0.42
LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluoride SCHEMBL944131 1.00 HSD17B10 (0.52) HSD17B10TDP1ALDH1A1KMT2AMEN1
Hydrochloric Acid SCHEMBL1851566 0.98 HSD17B10 (0.50) HSD17B10TDP1ALDH1A1KMT2AMEN1
SCHEMBL28592 0.98 HSD17B10 (0.54) HSD17B10TDP1ALDH1A1KMT2AMEN1
Fluoride SCHEMBL11797732 0.82 HSD17B10 (0.64) HSD17B10TDP1ALDH1A1KMT2AMEN1
Fluoride SCHEMBL27513971 0.82 HSD17B10 (0.64) HSD17B10TDP1ALDH1A1KMT2AMEN1
Fluoride SCHEMBL946835 0.80 TSHR (0.57) HSD17B10TDP1ALDH1A1KMT2AMEN1
SCHEMBL22566 0.79 HSD17B10 (0.67) HSD17B10TDP1ALDH1A1KMT2AMEN1
SCHEMBL29577518 0.79 HSD17B10 (0.67) HSD17B10TDP1ALDH1A1KMT2AMEN1
SCHEMBL16355165 0.79 HSD17B10 (0.67) HSD17B10TDP1ALDH1A1KMT2AMEN1
SCHEMBL9775860 0.77 TSHR (0.59) HSD17B10TDP1ALDH1A1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2675785-B1 INDUSTRIAL METHODS FOR PRODUCING ARYLSULFUR PENTAFLUORIDES UBE INDUSTRIES (JP) 2018-04-11 EP disclosed
US-9676710-B2 Industrial methods for producing arylsulfur pentafluorides UBE INDUSTRIES, LTD. (JP) 2017-06-13 US disclosed
US-9630920-B2 Industrial methods for producing arylsulfur pentafluorides UBE INDUSTRIES, LTD. (JP) 2017-04-25 US disclosed
US-9630919-B2 Industrial methods for producing arylsulfur pentafluorides UBE INDUSTRIES, LTD. (JP) 2017-04-25 US disclosed
US-20160362366-A1 Industrial Methods for Producing Arylsulfur Pentafluorides UBE CORPORATION (JP) 2016-12-15 US disclosed
US-20160362367-A1 Industrial Methods for Producing Arylsulfur Pentafluorides UBE CORPORATION (JP) 2016-12-15 US disclosed
US-20160362365-A1 Industrial Methods for Producing Arylsulfur Pentafluorides UBE CORPORATION (JP) 2016-12-15 US disclosed
US-9447034-B2 Industrial methods for producing arylsulfur pentafluorides UBE INDUSTRIES, LTD. (JP) 2016-09-20 US disclosed
US-20150315139-A1 Industrial Methods for Producing Arylsulfur Pentafluorides UBE CORPORATION (JP) 2015-11-05 US disclosed
US-9108910-B2 Industrial methods for producing arylsulfur pentafluorides UBE INDUSTRIES, LTD. (JP) 2015-08-18 US disclosed
US-20090287024-A1 Process for Producing Arylsulfur Pentafluorides IM&T RESEARCH, INC. (US) 2009-11-19 US disclosed
US-7592491-B2 Process for producing arylsulfur pentafluorides IM&T RESEARCH, INC. (US) 2009-09-22 US disclosed
WO-2008118787-A1 PROCESS FOR PRODUCING ARYLSULFUR PENTAFLUORIDES IM & T RESEARCH, INC. (US) 2008-10-02 WO disclosed
US-20080234520-A1 PROCESS FOR PRODUCING ARYLSULFUR PENTAFLUORIDES IM&T RESEARCH, INC. (US) 2008-09-25 US disclosed
US-7015176-B2 Process for the synthesis of aryl sulfurpentafluorides AIR PRODUCTS AND CHEMICALS, INC. (US) 2006-03-21 US disclosed
US-6958415-B2 Synthesis of pentafluorosulfuranyl arylenes AIR PRODUCTS AND CHEMICALS, INC. (US) 2005-10-25 US disclosed
EP-1533297-A1 Synthesis of pentafluorosulfuranyl arylenes AIR PRODUCTS AND CHEMICALS, INC. (US) 2005-05-25 EP disclosed
US-20050107632-A1 Synthesis of pentafluorosulfuranyl arylenes AIR PRODUCTS AND CHEMICALS, INC. 2005-05-19 US disclosed
US-20040249209-A1 Process for the synthesis of aryl sulfurpentafluorides AIR PRODUCTS AND CHEMICALS, INC. 2004-12-09 US disclosed
EP-1484318-A1 Process for the synthesis of aryl sulfurpentafluorides AIR PRODUCTS AND CHEMICALS, INC. (US) 2004-12-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090287024-A1 Process for Producing Arylsulfur Pentafluorides PFAS, MPST, ARSA HSD17B10 2421/4885TDP1 4179/4885ALDH1A1 2190/4885
US-20150315139-A1 Industrial Methods for Producing Arylsulfur Pentafluorides PFAS, ARSA, CYP2F1 HSD17B10 510/4885TDP1 2828/4885ALDH1A1 794/4885
US-20160362367-A1 Industrial Methods for Producing Arylsulfur Pentafluorides PFAS, ARSA, CYP2F1 HSD17B10 510/4885TDP1 2828/4885ALDH1A1 794/4885
US-20040249209-A1 Process for the synthesis of aryl sulfurpentafluorides PFAS, FLI1, AFF4 HSD17B10 3717/4885TDP1 3824/4885ALDH1A1 589/4885
US-20080234520-A1 PROCESS FOR PRODUCING ARYLSULFUR PENTAFLUORIDES PFAS, MPST, ARSA HSD17B10 2421/4885TDP1 4179/4885ALDH1A1 2190/4885
US-20160362365-A1 Industrial Methods for Producing Arylsulfur Pentafluorides PFAS, ARSA, CYP2F1 HSD17B10 510/4885TDP1 2828/4885ALDH1A1 794/4885
US-20160362366-A1 Industrial Methods for Producing Arylsulfur Pentafluorides PFAS, ARSA, CYP2F1 HSD17B10 510/4885TDP1 2828/4885ALDH1A1 794/4885
US-20050107632-A1 Synthesis of pentafluorosulfuranyl arylenes TST, DHRS9, HDHD5 HSD17B10 48/4885TDP1 4166/4885ALDH1A1 248/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.