Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT1 | P30419 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 7/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | QPCT | Q16769 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | SOD1 | P00441 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849431 | 0.82 | MAOA (0.56) | NMT1MAOAMAOBQPCTSMN1; SMN2 | |
| SCHEMBL9849804 | 0.75 | ALDH1A1 (0.56) | NMT1TBXAS1QPCTSMN1; SMN2NPC1 | |
| Fumaric Acid SCHEMBL9849283 | 0.74 | MEN1 (0.49) | TBXAS1SMN1; SMN2NPC1KDM4EMAPT | |
| SCHEMBL9849398 | 0.70 | L3MBTL1 (0.55) | NMT1TBXAS1SMN1; SMN2NPC1KDM4E | |
| SCHEMBL1066018 | 0.69 | HDAC1 (0.68) | ALDH1A1 | |
| SCHEMBL1066020 | 0.69 | HDAC1 (0.68) | ALDH1A1 | |
| SCHEMBL8348204 | 0.69 | HDAC1 (0.68) | ALDH1A1 | |
| SCHEMBL5189230 | 0.68 | QPCT (0.69) | MAOAMAOBQPCTSMN1; SMN2NPC1 | |
| SCHEMBL13472388 | 0.67 | TP53 (0.46) | TBXAS1SMN1; SMN2NPC1ALDH1A1SOD1 | |
| SCHEMBL4253264 | 0.65 | QPCT (0.50) | TBXAS1QPCTSMN1; SMN2NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0446604-A2 | Pyridine and related aza heterocycle derivatives as cardiovascular agents | AMERICAN CYANAMID COMPANY (US) | 1991-09-18 | — | — | EP | disclosed |