Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8697541 | 0.83 | HTT (0.53) | HTTRAB9AATMNPC1MAPT | |
| SCHEMBL8696904 | 0.81 | HTT (0.74) | HTTRAB9AATMNPC1MAPT | |
| SCHEMBL12166143 | 0.75 | MMP2 (0.53) | HTTRAB9AATMNPC1MAPT | |
| SCHEMBL9850650 | 0.75 | LMNA (0.54) | HTTRAB9AATMNPC1MAPT | |
| SCHEMBL16868407 | 0.74 | ALDH1A1 (0.52) | ATMMAPTSMN1; SMN2LMNACYP2D6 | |
| SCHEMBL23190950 | 0.73 | SLC6A2 (0.50) | HTTRAB9AATMSMN1; SMN2LMNA | |
| SCHEMBL10589581 | 0.73 | HTT (0.83) | HTTRAB9AATMNPC1MAPT | |
| SCHEMBL3129690 | 0.72 | ALDH1A1 (0.59) | HTTRAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL8698366 | 0.72 | HTT (0.51) | HTTRAB9AATMNPC1MAPT | |
| SCHEMBL18754480 | 0.72 | ALDH1A1 (0.42) | HTTRAB9AATMNPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0423524-A2 | Propiophenone derivatives and their preparation and pharmaceutical use | MARUHO Co., Ltd. (JP) | 1991-04-24 | — | — | EP | disclosed |