Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | APP | P05067 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11117595 | 0.82 | PTGS1 (0.47) | PTGS1PTGS2MAPTALDH1A1KDM4E | |
| SCHEMBL7074465 | 0.78 | PTGS1 (0.54) | PTGS1PTGS2ALDH1A1MEN1KMT2A | |
| SCHEMBL10446089 | 0.78 | GFER (0.49) | GFERAXLPTGS1PTGS2MAPT | |
| SCHEMBL10445819 | 0.77 | GFER (0.47) | GFERAXLPTGS1PTGS2MAPT | |
| SCHEMBL11117152 | 0.73 | MAOB (0.41) | PTGS1PTGS2MAPTMAPK1RAB9A | |
| SCHEMBL11113691 | 0.73 | LOXL2 (0.48) | PTGS1PTGS2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9852620 | 0.72 | GAA (0.35) | PTGS1PTGS2MAPTALDH1A1MEN1 | |
| SCHEMBL30230180 | 0.69 | EPHX2 (0.50) | GFERAXLMAPTALDH1A1KDM4E | |
| SCHEMBL9255622 | 0.68 | GFER (0.66) | GFERAXLMAPTALDH1A1KDM4E | |
| SCHEMBL1903862 | 0.68 | EPHX2 (0.52) | GFERAXLPTGS1PTGS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0444764-A1 | Process and intermediates for the preparation of substituted 1-benzothiazolyl-3,4-dimethyl-3-pyrrolin-2,5(1H)-diones | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-09-04 | — | — | EP | disclosed |