Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 13/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | RGS12 | O14924 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9853392 | 0.81 | MEN1 (0.53) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10696644 | 0.77 | ADORA2B (0.65) | ADORA2BADORA3ADORA1ADORA2APDE4A | |
| SCHEMBL7320101 | 0.75 | MEN1 (0.52) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL12152136 | 0.75 | PDE4A (0.40) | ADORA2BADORA3ADORA1ADORA2APDE4A | |
| SCHEMBL8914154 | 0.71 | MEN1 (0.57) | MEN1KMT2AKDM4ENPC1ALDH1A1 | |
| SCHEMBL3848063 | 0.70 | ADORA2B (0.60) | ADORA2BADORA3ADORA1ADORA2APDE4A | |
| SCHEMBL4445212 | 0.69 | KDM4E (0.51) | ADORA2BADORA3ADORA2APDE4APDE4B | |
| SCHEMBL5867203 | 0.69 | TSHR (0.48) | MEN1KMT2AUSP2ALDH1A1POLB | |
| SCHEMBL837200 | 0.68 | ADORA2B (0.45) | ADORA2BADORA3ADORA1ADORA2APDE4A | |
| SCHEMBL23202393 | 0.67 | MEN1 (0.47) | ADORA2BADORA3ADORA1ADORA2APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4965271-A | Method of inhibiting the activity of leukocyte derived cytokines | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-10-23 | — | — | US | claimed |
| EP-0421587-A2 | Xanthine derivatives used in asthma | Beecham Group p.l.c. (GB) | 1991-04-10 | — | — | EP | disclosed |