Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | BRD2 | P25440 | 2/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.44 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9853392 | 0.93 | MEN1 (0.53) | MEN1KMT2ANPSR1GAAALDH1A1 | |
| SCHEMBL8914154 | 0.88 | MEN1 (0.57) | MEN1KMT2ANPSR1GAAALDH1A1 | |
| SCHEMBL9298051 | 0.86 | ALDH1A1 (0.47) | MEN1KMT2ANPSR1GAAALDH1A1 | |
| SCHEMBL5093687 | 0.81 | HPGD (0.54) | NPSR1GAAALDH1A1POLBRAB9A | |
| SCHEMBL19066314 | 0.77 | MEN1 (0.65) | MEN1KMT2ANPSR1GAAALDH1A1 | |
| SCHEMBL9853394 | 0.75 | ADORA2B (0.45) | MEN1KMT2AALDH1A1NPC1POLB | |
| SCHEMBL9171903 | 0.75 | MAPT (0.47) | MEN1KMT2ANPSR1GAAALDH1A1 | |
| SCHEMBL19066322 | 0.74 | RXFP1 (0.59) | MEN1KMT2ANPSR1GAAALDH1A1 | |
| SCHEMBL1822005 | 0.74 | SMN1; SMN2 (0.48) | NPSR1GAAALDH1A1HPGDHSD17B10 | |
| SCHEMBL9843261 | 0.74 | TPH1 (0.41) | MEN1KMT2AALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0485495-A1 | USE OF XANTHINE-DERIVATIVES AS INHIBITORS OF INDUCED BLOOD EOSINOPHILIA | Beecham Group p.l.c. (GB) | 1992-05-20 | — | — | EP | claimed |
| WO-1991001730-A2 | USE OF XANTHINE-DERIVATIVES AS INHIBITORS OF INDUCED BLOOD EOSINOPHILIA | BEECHAM GROUP PLC (GB) | 1991-02-21 | — | — | WO | claimed |
| EP-0173039-A2 | Use of xanthine and thioxanthine derivatives for the preparation of medicaments | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1986-03-05 | — | — | EP | claimed |
| EP-0485495-A1 | USE OF XANTHINE-DERIVATIVES AS INHIBITORS OF INDUCED BLOOD EOSINOPHILIA | Beecham Group p.l.c. (GB) | 1992-05-20 | — | — | EP | disclosed |
| WO-1991001730-A2 | USE OF XANTHINE-DERIVATIVES AS INHIBITORS OF INDUCED BLOOD EOSINOPHILIA | BEECHAM GROUP PLC (GB) | 1991-02-21 | — | — | WO | disclosed |