SCHEMBL9856019

SCHEMBL9856019

CC(C)=CCSc1ccc(SCCN)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.35
MAPK1 P28482 1/20 0.35
MTNR1A P48039 2/20 0.35
MTNR1B P49286 2/20 0.35
NOS1 P29475 1/20 0.34
METAP2 P50579 4/20 0.33
CYP1A2 P05177 2/20 0.33
CYP3A4 P08684 2/20 0.33
ICMT O60725 1/20 0.33
GMNN O75496 1/20 0.33
TRPA1 O75762 1/20 0.33
LMNA P02545 1/20 0.33
POLB P06746 1/20 0.33
MAPT P10636 1/20 0.33
CYP2C9 P11712 1/20 0.33
TSHR P16473 1/20 0.33
NFKB1 P19838 1/20 0.33
CDK2 P24941 1/20 0.33
RECQL P46063 1/20 0.33
BLM P54132 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9856231 0.83 CA2 (0.44) ALDH1A1MAPK1MTNR1AMTNR1BMETAP2
SCHEMBL9189810 0.79 CA2 (0.41) ALDH1A1NOS1METAP2CYP1A2CYP3A4
SCHEMBL9856215 0.78 KDM4E (0.43) ALDH1A1MTNR1AMTNR1BLMNAMAPT
SCHEMBL4313725 0.78 ALDH1A1 (0.48) ALDH1A1MAPK1MTNR1AMTNR1BMETAP2
SCHEMBL9856252 0.77 METAP2 (0.35) MTNR1AMTNR1BNOS1METAP2CYP1A2
SCHEMBL3667550 0.77 ALDH1A1 (0.48) ALDH1A1MAPK1CYP1A2CYP3A4CYP2C9
SCHEMBL5846711 0.77 SMN1; SMN2 (0.44) ALDH1A1METAP2CYP1A2CYP3A4ICMT
SCHEMBL9856329 0.74 MTNR1A (0.50) ALDH1A1MAPK1MTNR1AMTNR1BCYP1A2
SCHEMBL6091563 0.73 METAP2 (0.33) METAP2CYP1A2CYP3A4ICMTGMNN
SCHEMBL9856327 0.73 MTNR1A (0.53) ALDH1A1MAPK1MTNR1AMTNR1BCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5037991-A Insecticides SANDOZ LTD. (CH) 1991-08-06 US disclosed
US-4968829-A ANTHELMINTICS, PARASITICIDES, NEMATOCIDES SANDOZ LTD. (CH) 1990-11-06 US disclosed