Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CFD | P00746 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.34 |
| ▸ | UBE2N | P61088 | 1/20 | 0.34 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.34 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9856945 | 0.78 | HTR2A (0.49) | HTR2AHRH1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL9857027 | 0.75 | HTR2A (0.49) | HTR2AHRH1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9856674 | 0.73 | TAAR1 (0.49) | HTR2AHRH1SIGMAR1TAAR1CFD | |
| SCHEMBL9857050 | 0.71 | TAAR1 (0.42) | HTR2AHRH1SIGMAR1TAAR1UBE2N | |
| SCHEMBL9856649 | 0.71 | HTR2A (0.41) | HTR2AHRH1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL9856602 | 0.71 | CYP2D6 (0.45) | HTR2AHRH1SIGMAR1TAAR1MEN1 | |
| SCHEMBL9856681 | 0.69 | HTR2A (0.45) | HTR2AHRH1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9856457 | 0.69 | HTR2A (0.51) | HTR2AHRH1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL9857014 | 0.69 | TAAR1 (0.54) | HTR2AHRH1SLC6A2SLC6A4TAAR1 | |
| SCHEMBL9856815 | 0.68 | SLC6A9 (0.54) | HTR2ASIGMAR1SLC6A4MAPTUTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0318233-A2 | Improvements in or relating to serotonin and norepinephrine uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |