Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1425864 | 0.89 | KDM4E (0.46) | NOS3NOS1NOS2KDM4ESMN1; SMN2 | |
| SCHEMBL4751608 | 0.87 | MAPT (0.44) | NOS3NOS1NOS2KDM4ESMN1; SMN2 | |
| SCHEMBL1182615 | 0.85 | SMN1; SMN2 (0.42) | NOS3NOS1NOS2KDM4ESMN1; SMN2 | |
| SCHEMBL2994626 | 0.83 | ALDH1A1 (0.41) | NOS3NOS1NOS2KDM4ESMN1; SMN2 | |
| SCHEMBL12563513 | 0.83 | ALDH1A1 (0.41) | NOS3NOS1NOS2KDM4ESMN1; SMN2 | |
| SCHEMBL2994625 | 0.83 | ALDH1A1 (0.41) | NOS3NOS1NOS2KDM4ESMN1; SMN2 | |
| SCHEMBL12636631 | 0.81 | ALDH1A1 (0.43) | NOS3NOS1NOS2KDM4ESMN1; SMN2 | |
| SCHEMBL1193762 | 0.81 | ALDH1A1 (0.40) | NOS3NOS1NOS2KDM4ESMN1; SMN2 | |
| SCHEMBL1193758 | 0.81 | ALDH1A1 (0.40) | NOS3NOS1NOS2KDM4ESMN1; SMN2 | |
| SCHEMBL1193760 | 0.81 | ALDH1A1 (0.40) | NOS3NOS1NOS2KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035792-B2 | Resorcinol derivative as HSP90 inhibitor | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-07-31 | — | — | US | disclosed |
| US-10035792-B2 | Resorcinol derivative as HSP90 inhibitor | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-07-31 | — | — | US | disclosed |
| US-10035792-B2 | Resorcinol derivative as HSP90 inhibitor | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-07-31 | — | — | US | disclosed |
| US-20180009794-A1 | Resorcinol Derivative As HSP90 Inhibitor | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-01-11 | — | — | US | disclosed |
| US-20180009794-A1 | Resorcinol Derivative As HSP90 Inhibitor | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-01-11 | — | — | US | disclosed |
| EP-3248968-A1 | RESORCINOL DERIVATIVE AS HSP90 INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2017-11-29 | — | — | EP | disclosed |
| EP-3248968-A1 | RESORCINOL DERIVATIVE AS HSP90 INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2017-11-29 | — | — | EP | disclosed |
| WO-2016116061-A1 | RESORCINOL DERIVATIVE AS HSP90 INHIBITOR | 南京明德新药研发股份有限公司 | 2016-07-28 | — | — | WO | disclosed |
| EP-1981337-B1 | THIOPHENYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | ATHERSYS INC (US) | 2015-09-02 | — | — | EP | disclosed |
| EP-1981337-B1 | THIOPHENYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | ATHERSYS INC (US) | 2015-09-02 | — | — | EP | disclosed |
| US-20070254868-A1 | C-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-11-01 | — | — | US | disclosed |
| US-20070254868-A1 | C-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-11-01 | — | — | US | disclosed |
| WO-2007111904-A2 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-04 | — | — | WO | disclosed |
| US-20070191342-A1 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | ATHERSYS, INC. | 2007-08-16 | — | — | US | disclosed |
| US-20070191342-A1 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | ATHERSYS, INC. | 2007-08-16 | — | — | US | disclosed |
| US-20070191342-A1 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | ATHERSYS, INC. | 2007-08-16 | — | — | US | disclosed |
| WO-2007084622-A2 | THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF | ATHERSYS, INC. (US) | 2007-07-26 | — | — | WO | disclosed |
| EP-1778243-A2 | SUBSTITUTED AZEPINE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS | Athersys, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006004931-A2 | SUBSTITUTED AZEPINE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS | ATHERSYS, INC. (US) | 2006-01-12 | — | — | WO | disclosed |
| US-20060003990-A1 | Substituted azepine derivatives as serotonin receptor modulators | ATHERSYS, INC. | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060003990-A1 | Substituted azepine derivatives as serotonin receptor modulators | HTR5A, HTR4, HTR7 | NOS3 1620/4885NOS1 2166/4885NOS2 2218/4885 |
| US-10035792-B2 | Resorcinol derivative as HSP90 inhibitor | HSP90AB1, HSP90AA1, HSP90AB2P | NOS3 2501/4885NOS1 1811/4885NOS2 1580/4885 |
| US-20180009794-A1 | Resorcinol Derivative As HSP90 Inhibitor | HSP90AB1, HSP90AA1, HSP90AB2P | NOS3 2501/4885NOS1 1811/4885NOS2 1580/4885 |
| US-20070191342-A1 | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof | HTR2C, HTR5A, HTR2A | NOS3 1373/4885NOS1 2092/4885NOS2 1114/4885 |
| US-20070254868-A1 | C-MET protein kinase inhibitors | MET, PRKCH, ABL1 | NOS3 2861/4885NOS1 3230/4885NOS2 2664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.