Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL158178 | 0.86 | — | — | |
| Bromide SCHEMBL10718877 | 0.84 | P2RX7 (0.52) | P2RX7CTNNB1WNT3APARP1KDM4E | |
| Ammonia Solution, Strong SCHEMBL17104818 | 0.84 | P2RX7 (0.52) | P2RX7CTNNB1WNT3APARP1KDM4E | |
| SCHEMBL27431959 | 0.84 | P2RX7 (0.52) | P2RX7CTNNB1WNT3APARP1KDM4E | |
| Hydrochloric Acid SCHEMBL27440453 | 0.84 | P2RX7 (0.52) | P2RX7CTNNB1WNT3APARP1KDM4E | |
| Hydrochloric Acid SCHEMBL25337662 | 0.84 | P2RX7 (0.52) | P2RX7CTNNB1WNT3APARP1KDM4E | |
| Pyrrole SCHEMBL4100621 | 0.83 | P2RX7 (0.32) | P2RX7CSNK1A1TYRO3DYRK1BADORA3 | |
| Imidazole SCHEMBL14714358 | 0.80 | ALDH1A1 (0.48) | P2RX7CTNNB1WNT3APARP1CSNK1A1 | |
| Pyrazole SCHEMBL357858 | 0.78 | P2RX7 (0.39) | P2RX7CTNNB1WNT3APARP1CSNK1A1 | |
| Pyrrole SCHEMBL1194080 | 0.76 | CES2 (0.53) | CTNNB1WNT3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9062088-B2 | CDK-inhibiting pyrrolopyrimidine carboxamide derivative or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing the same as active ingredient for preventing or treating hepatocellular carcinoma | SNU R&DB FOUNDATION (KR) | 2015-06-23 | — | — | US | claimed |
| EP-4720066-A1 | PYRROLOPYRIMIDINE CARBOXAMIDES | Astrazeneca AB (SE) | 2026-04-08 | — | — | EP | disclosed |
| WO-2024252276-A1 | PYRROLOPYRIMIDINE CARBOXAMIDES | ASTRAZENECA AB (SE) | 2024-12-12 | — | — | WO | disclosed |
| US-20200123499-A1 | METHOD FOR EFFICIENT GENERATION OF NEURONS FROM NON-NEURONAL CELLS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2020-04-23 | — | — | US | disclosed |
| WO-2017096326-A1 | METHOD FOR EFFICIENT GENERATION OF NEURONS FROM NON-NEURONAL CELLS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2017-06-08 | — | — | WO | disclosed |
| CN-103582644-B | Phthalazinone-Pyrrolopyrimidine Carboxamide Derivatives | 塔科达有限责任公司 | 2016-07-20 | — | — | CN | disclosed |
| US-9376442-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-20160108049-A1 | Novel Phthalazinone-Pyrrolopyrimidinecarboxamide Derivatives | ASTRAZENECA AB (SE) | 2016-04-21 | — | — | US | disclosed |
| EP-2721030-B1 | NOVEL PHTHALAZINONE-PYRROLOPYRIMIDINECARBOXAMIDE DERIVATIVES | TAKEDA GMBH (DE) | 2015-12-16 | — | — | EP | disclosed |
| CN-102574861-B | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2015-08-05 | — | — | CN | disclosed |
| CN-101959890-B | Pyrrolopyrimidine carboxamides | NYCOMED GMBH | 2013-10-30 | — | — | CN | disclosed |
| CN-101959890-B | Pyrrolopyrimidine carboxamides | NYCOMED GMBH | 2013-10-30 | — | — | CN | disclosed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| EP-2470536-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2012-07-04 | — | — | EP | disclosed |
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
| WO-2011023693-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-03-03 | — | — | WO | disclosed |
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-01-27 | — | — | US | disclosed |
| CN-101959890-A | Pyrrolopyrimidine carboxamides | NYCOMED GMBH | 2011-01-26 | — | — | CN | disclosed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE3A, PDE2A | P2RX7 494/4885CTNNB1 4377/4885WNT3A 4421/4885 |
| US-20160108049-A1 | Novel Phthalazinone-Pyrrolopyrimidinecarboxamide Derivatives | PDE4A, PDE4B, PDE5A | P2RX7 205/4885CTNNB1 4185/4885WNT3A 4406/4885 |
| US-20120149721-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE12, PDE4A | P2RX7 778/4885CTNNB1 4500/4885WNT3A 4586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.