Sugi Predict

Sugi Predict / Compounds / SCHEMBL9860903

SCHEMBL9860903

SCHEMBL9860903

O=C(Cl)c1ccc(Cl)c(F)c1F

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 3/20 0.55
▸ USP2 O75604 1/20 0.55
▸ ALDH1A1 P00352 5/20 0.45
▸ ALOX15 P16050 1/20 0.45
▸ CES2 O00748 3/20 0.41
▸ CES1 P23141 3/20 0.41
▸ KMT2A Q03164 1/20 0.35
▸ ATM Q13315 1/20 0.35
▸ SORT1 Q99523 1/20 0.35
▸ TP53 P04637 1/20 0.34
▸ TSHR P16473 1/20 0.34
▸ CASP1 P29466 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ NOTUM Q6P988 1/20 0.33
▸ KAT6A Q92794 1/20 0.32
▸ ADRA2A P08913 1/20 0.32
▸ CLCN2 P51788 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29544731 1.00 HPGD (0.55) HPGDUSP2ALDH1A1ALOX15CES2
SCHEMBL106507 0.84 HPGD (0.44) HPGDUSP2ALDH1A1ALOX15CES2
SCHEMBL7938468 0.84 ALDH1A1 (0.43) HPGDUSP2ALDH1A1ALOX15CES2
SCHEMBL20721983 0.82 HPGD (0.55) HPGDUSP2ALDH1A1CES2CES1
SCHEMBL7749589 0.82 HPGD (0.55) HPGDUSP2ALDH1A1CES2CES1
SCHEMBL9712390 0.81 HPGD (0.42) HPGDUSP2ALDH1A1ALOX15CES2
SCHEMBL29454770 0.80 ALDH1A1 (0.54) ALDH1A1ALOX15CES2CES1KMT2A
SCHEMBL413285 0.80 ALDH1A1 (0.54) ALDH1A1ALOX15CES2CES1KMT2A
SCHEMBL31410035 0.80 HPGD (0.53) HPGDUSP2ALDH1A1CES2CES1
Hydrochloric Acid SCHEMBL9860913 0.80 HPGD (0.53) HPGDUSP2ALDH1A1CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250388595-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2B, COMPOSITIONS AND METHODS DENALI THERAPEUTICS INC (US) 2025-12-25 — — US disclosed
EP-3782994-B1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY INC (US) 2025-07-16 — — EP disclosed
US-20250090500-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2025-03-20 — — US disclosed
US-12220401-B2 Compounds useful as kinase inhibitors LOXO ONCOLOGY, INC. (US) 2025-02-11 — — US disclosed
CN-118239937-A Compounds, compositions, and methods 戴纳立制药公司 2024-06-25 — — CN disclosed
CN-118239938-A Compounds, compositions, and methods 戴纳立制药公司 2024-06-25 — — CN disclosed
CN-111094233-B Compounds, compositions, and methods 戴纳立制药公司 2024-03-15 — — CN disclosed
US-11851440-B2 Modulators of eukaryotic initiation factor 2B, compositions and methods DENALI THERAPEUTICS INC. (US) 2023-12-26 — — US disclosed
US-11826351-B2 Compounds useful as kinase inhibitors LOXO ONCOLOGY INC. (US) 2023-11-28 — — US disclosed
US-20230372298-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2023-11-23 — — US disclosed
WO-2019032743-A1 COMPOUNDS, COMPOSITIONS AND METHODS DENALI THERAPEUTICS INC. (US) 2019-02-14 — — WO disclosed
US-20190000806-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2019-01-03 — — US disclosed
US-20180362512-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS LOXO ONCOLOGY, INC. 2018-12-20 — — US disclosed
EP-3390395-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS Loxo Oncology Inc. (US) 2018-10-24 — — EP disclosed
CN-108473481-A compounds useful as kinase inhibitors 洛克索肿瘤学股份有限公司 2018-08-31 — — CN disclosed
WO-2017103611-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS REDX PHARMA PLC (GB) 2017-06-22 — — WO disclosed
CN-106661035-A Pyrazolopyrimidine derivatives as inhibitors of bruton's tyrosine kinase 莱德克斯制药公共有限公司 2017-05-10 — — CN disclosed
CN-1041083-C Prepn. of beta-ketoesters useful in preparing quinolone antibiotics PFIZER (US) 1998-12-09 — — CN disclosed
CN-1055177-A Be used to prepare the preparation method of the 'beta '-ketoester compounds of quinolone antibiotic PFIZER (US) 1991-10-09 — — CN disclosed
EP-0449445-A2 Preparation of beta-ketoesters useful in preparing quinolone antibiotics PFIZER INC. (US) 1991-10-02 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12220401-B2 Compounds useful as kinase inhibitors BTK, ABL1, LCK HPGD 4214/4885USP2 3460/4885ALDH1A1 4454/4885
US-20250090500-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, ABL1, LCK HPGD 4214/4885USP2 3460/4885ALDH1A1 4454/4885
US-20180362512-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, ABL1, LCK HPGD 4214/4885USP2 3460/4885ALDH1A1 4454/4885
US-11851440-B2 Modulators of eukaryotic initiation factor 2B, compositions and methods EIF4EBP1, EIF4B, EIF2B2 HPGD 3313/4885USP2 2192/4885ALDH1A1 4576/4885
US-20250388595-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2B, COMPOSITIONS AND METHODS EIF2B1, EIF4EBP1, EIF2B3 HPGD 3393/4885USP2 3134/4885ALDH1A1 4400/4885
US-11826351-B2 Compounds useful as kinase inhibitors BTK, ABL1, LCK HPGD 4214/4885USP2 3460/4885ALDH1A1 4454/4885
US-20230372298-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, ABL1, LCK HPGD 4214/4885USP2 3460/4885ALDH1A1 4454/4885
US-20190000806-A1 COMPOUNDS USEFUL AS KINASE INHIBITORS BTK, ABL1, LCK HPGD 4214/4885USP2 3460/4885ALDH1A1 4454/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.