Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10445064 | 0.79 | MAOB (0.44) | PDE5AMAOBBCHEMAOAACHE | |
| Fumaric Acid SCHEMBL9865075 | 0.79 | MAOB (0.44) | PDE5AMAOBBCHEMAOAACHE | |
| Fumaric Acid SCHEMBL9603068 | 0.76 | ALDH1A1 (0.34) | TOP1 | |
| Fumaric Acid SCHEMBL9603065 | 0.76 | ALDH1A1 (0.34) | TOP1 | |
| SCHEMBL9602515 | 0.74 | ALDH1A1 (0.33) | TOP1ACHE | |
| SCHEMBL9867304 | 0.74 | MAOA (0.35) | TOP1MAOBMAOAACHE | |
| SCHEMBL9603188 | 0.74 | MAPT (0.37) | PTGS2PTGS1ACHEPDE4APDE4B | |
| SCHEMBL9602794 | 0.71 | CHRM2 (0.32) | PTGS1PDE4APDE4BPDE4CPDE4D | |
| Fumaric Acid SCHEMBL9866359 | 0.71 | ALDH1A1 (0.33) | — | |
| Maleic Acid SCHEMBL9866351 | 0.71 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |