SCHEMBL8999360

SCHEMBL8999360

CS(=O)(=O)c1nc(-c2ccc([N+](=O)[O-])cc2)ns1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.48
LMNA P02545 1/20 0.48
KMT2A Q03164 1/20 0.48
TNFSF10 P50591 1/20 0.43
CA12 O43570 3/20 0.42
CA1 P00915 3/20 0.42
CA2 P00918 3/20 0.42
CA9 Q16790 3/20 0.42
CA14 Q9ULX7 2/20 0.42
XDH P47989 1/20 0.42
PTGS2 P35354 4/20 0.41
APP P05067 1/20 0.41
MAPT P10636 4/20 0.40
RAB9A P51151 4/20 0.40
NPC1 O15118 3/20 0.40
IDO1 P14902 1/20 0.40
XBP1 P17861 1/20 0.40
HTT P42858 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9867247 0.85 CA2 (0.54) CA12CA1CA2CA9CA14
SCHEMBL8999461 0.78 PLCG1 (0.51) MEN1LMNAKMT2ACA12CA2
SCHEMBL8999409 0.78 RAB9A (0.53) MEN1LMNAKMT2APTGS2RAB9A
SCHEMBL7695561 0.77 ADORA3 (0.52) MEN1LMNAKMT2AMAPTRAB9A
SCHEMBL8806142 0.76 XDH (0.45) LMNATNFSF10XDHAPPMAPT
SCHEMBL11423635 0.76 ADORA3 (0.56) MEN1LMNAKMT2ACA12CA1
SCHEMBL10749315 0.76 CASP3 (0.48) MEN1LMNAKMT2ATNFSF10XDH
SCHEMBL24217326 0.76 F2RL3 (0.49) MEN1LMNAKMT2ATNFSF10XDH
SCHEMBL8999506 0.76 TNFSF10 (0.49) MEN1KMT2ATNFSF10XDHAPP
SCHEMBL31126515 0.75 RARA (0.45) MEN1LMNAKMT2ACA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5332430-A Use of thiadiazole compounds as an antifouling active ingredient WITCO GMBH (DE) 1994-07-26 US claimed
US-10308891-B2 Hydraulic fluid compositions HOUGHTON TECHNICAL CORP. (US) 2019-06-04 US disclosed
US-20160208193-A1 HYDRAULIC FLUID COMPOSITIONS BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT 2016-07-21 US disclosed
EP-3039103-A2 HYDRAULIC FLUID COMPOSITIONS Houghton Technical Corp. (US) 2016-07-06 EP disclosed
WO-2015031052-A2 HYDRAULIC FLUID COMPOSITIONS HOUGHTON TECHNICAL CORP. (US) 2015-03-05 WO disclosed
EP-0588007-B1 Use of thiadiazoles as antifouling agent WITCO GMBH (DE) 1996-09-11 EP disclosed
US-5332430-A Use of thiadiazole compounds as an antifouling active ingredient WITCO GMBH (DE) 1994-07-26 US disclosed
EP-0588007-A1 Use of thiadiazoles as antifouling agent Witco GmbH (DE) 1994-03-23 EP disclosed