Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9867365 | 1.00 | DRD2 (0.52) | DRD2 | |
| SCHEMBL9868670 | 0.94 | DRD2 (0.58) | DRD2 | |
| SCHEMBL11265595 | 0.81 | DRD2 (0.59) | DRD2 | |
| Fumaric Acid SCHEMBL7266664 | 0.81 | DRD2 (0.55) | DRD2 | |
| Fumaric Acid SCHEMBL9718068 | 0.81 | DRD2 (0.55) | DRD2 | |
| Water SCHEMBL11269883 | 0.81 | DRD2 (0.58) | DRD2 | |
| SCHEMBL11356294 | 0.80 | HTR4 (0.61) | DRD2 | |
| Hydrochloric Acid SCHEMBL11265728 | 0.79 | HTR4 (0.60) | DRD2 | |
| Phosphoric Acid SCHEMBL11259891 | 0.79 | DRD2 (0.56) | DRD2 | |
| Fumaric Acid SCHEMBL9718059 | 0.79 | DRD2 (0.53) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006570-A | Dihydrobenzofuran- and chroman-carboxamide derivatives, processes for the preparation thereof and use thereof as neuroleptics | LABORATOIRES DELAGRANGE (FR) | 1991-04-09 | — | — | US | disclosed |