Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NR1D1 | P20393 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866691 | 0.81 | LTA4H (0.47) | NPSR1NR1D1 | |
| SCHEMBL4959583 | 0.81 | NR1D1 (0.50) | NR1D1TP53 | |
| SCHEMBL23343522 | 0.81 | NR1D1 (0.50) | NR1D1TP53 | |
| SCHEMBL9868101 | 0.79 | ALDH1A1 (0.44) | ALDH1A1HPGDTSHRNPC1MAPT | |
| SCHEMBL4145687 | 0.79 | MEN1 (0.41) | ALDH1A1HPGDTSHRMAPTMAPK1 | |
| SCHEMBL4150077 | 0.72 | ROCK1 (0.38) | ALDH1A1HPGDMAPTHSD17B10NR1D1 | |
| SCHEMBL13077629 | 0.72 | TSHR (0.46) | ALDH1A1HPGDTSHRLMNAMAPT | |
| SCHEMBL433888 | 0.71 | MTNR1A (0.54) | ALDH1A1TSHRLMNANR1D1 | |
| SCHEMBL14301648 | 0.70 | NR1D1 (0.44) | MAPTNR1D1TP53SMN1; SMN2 | |
| SCHEMBL23182808 | 0.70 | NPC1 (0.48) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5017584-A | Antidepressant 2-(4,5-dihydro-1H-imidazolyl)-dihydro-1H-indoles, -1,2,3,4-tetrahydroquinolines and -1H-indoles, and methods of use thereas | STERLING DRUG INC. (US) | 1991-05-21 | — | — | US | disclosed |