Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9868255 | 1.00 | MEN1 (0.44) | MEN1KMT2ADRD1MAPTRAB9A | |
| SCHEMBL9337098 | 0.78 | SGMS2 (0.43) | DRD1 | |
| SCHEMBL7770156 | 0.77 | DRD1 (0.45) | MEN1KMT2ADRD1 | |
| SCHEMBL4446308 | 0.77 | MRGPRX4 (0.58) | RAB9A | |
| SCHEMBL9523919 | 0.76 | PARP1 (0.49) | DRD1RAB9A | |
| SCHEMBL9332789 | 0.76 | KLKB1 (0.51) | MEN1KMT2ADRD1 | |
| SCHEMBL9335569 | 0.75 | KMT2A (0.44) | MEN1KMT2A | |
| SCHEMBL7774816 | 0.74 | DRD1 (0.49) | MEN1KMT2ADRD1 | |
| SCHEMBL9867733 | 0.74 | RXRA (0.45) | MEN1KMT2AMAPT | |
| SCHEMBL9335256 | 0.74 | TDP2 (0.55) | MEN1KMT2ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991017162-A1 | IMIDAZOPYRIDINE PAF ANTAGONISTS | PFIZER LIMITED (GB) | 1991-11-14 | — | — | WO | disclosed |