Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL258223 | 0.86 | ALDH1A1 (0.55) | POLBALDH1A1CYP2C9SMN1; SMN2RAB9A | |
| SCHEMBL158842 | 0.86 | POLB (0.49) | POLBALDH1A1CYP2C9SMN1; SMN2RAB9A | |
| SCHEMBL2306128 | 0.83 | SYK (0.48) | POLBALDH1A1CYP2C9SMN1; SMN2RAB9A | |
| SCHEMBL4489937 | 0.81 | P2RX7 (0.55) | POLBALDH1A1CYP2C9SMN1; SMN2RAB9A | |
| Hydrochloric Acid SCHEMBL11508163 | 0.81 | SYK (0.46) | POLBALDH1A1CYP2C9SMN1; SMN2RAB9A | |
| Salicylic Acid SCHEMBL810603 | 0.80 | ALDH1A1 (0.56) | POLBALDH1A1CYP2C9SMN1; SMN2RAB9A | |
| SCHEMBL9869479 | 0.80 | L3MBTL1 (0.47) | POLBALDH1A1CYP2C9SMN1; SMN2RAB9A | |
| SCHEMBL4500023 | 0.80 | L3MBTL1 (0.60) | POLBALDH1A1CYP2C9RAB9ALMNA | |
| SCHEMBL9869490 | 0.79 | KDM4E (0.45) | POLBALDH1A1CYP2C9SMN1; SMN2RAB9A | |
| SCHEMBL6069713 | 0.78 | POLB (0.43) | POLBALDH1A1CYP2C9SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006532-A | Enzyme inhibitor; antiinflammatory agents | MERCK & CO. INC., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4904672-A | Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4767766-A | Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1988-08-30 | — | — | US | disclosed |