Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | BRS3 | P32247 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9871188 | 0.90 | KDM4E (0.37) | HTTTP53GAACYP1A2RAB9A | |
| SCHEMBL9871084 | 0.87 | APP (0.37) | HTTGAACYP1A2MAPTALDH1A1 | |
| SCHEMBL9870642 | 0.84 | LMNA (0.44) | GAARAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL9872191 | 0.83 | MAPT (0.38) | HTTGAARAB9ANPC1MAPT | |
| SCHEMBL8793570 | 0.82 | LMNA (0.45) | GAARAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL9870774 | 0.77 | ACHE (0.40) | HTTGAAMAPTALDH1A1NPSR1 | |
| SCHEMBL9872179 | 0.77 | MAPT (0.33) | HTTGAAMAPTALDH1A1NPSR1 | |
| SCHEMBL8792401 | 0.77 | HTT (0.42) | HTTTP53CYP1A2RAB9ANPC1 | |
| SCHEMBL8793431 | 0.77 | NPC1 (0.45) | HTTTP53GAACYP1A2RAB9A | |
| SCHEMBL10964096 | 0.73 | SMN1; SMN2 (0.39) | HTTGAAALDH1A1NPSR1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011835-A | Substituted triazolopyridazines, pharmaceutical compositions and use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-30 | — | — | US | claimed |
| US-5011835-A | Substituted triazolopyridazines, pharmaceutical compositions and use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-30 | — | — | US | disclosed |