Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.34 |
| ▸ | HPGD | P15428 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870642 | 0.99 | LMNA (0.44) | LMNAALDH1A1HPGDMAPTPKM | |
| SCHEMBL9870788 | 0.92 | KDM4E (0.42) | LMNAALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL9872191 | 0.88 | MAPT (0.38) | LMNAALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL9871963 | 0.82 | HTT (0.40) | LMNAALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL9871188 | 0.75 | KDM4E (0.37) | LMNAALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL9870774 | 0.73 | ACHE (0.40) | LMNAALDH1A1HPGDMAPTKDM4E | |
| SCHEMBL9872179 | 0.71 | MAPT (0.33) | ALDH1A1HPGDMAPTPKMKDM4E | |
| SCHEMBL8794028 | 0.71 | KMT2A (0.54) | LMNAKDM4ENPC1RAB9APOLB | |
| SCHEMBL10964096 | 0.70 | SMN1; SMN2 (0.39) | ALDH1A1NPSR1USP2GAAPOLB | |
| SCHEMBL9871763 | 0.66 | ALDH1A1 (0.35) | LMNAALDH1A1HPGDMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011835-A | Substituted triazolopyridazines, pharmaceutical compositions and use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-30 | — | — | US | claimed |
| EP-0441339-B1 | Substituted triazolopyridazines | MERRELL PHARMA INC (US) | 1997-08-20 | — | — | EP | disclosed |
| EP-0441339-A1 | Substituted triazolopyridazines | MERRELL PHARMACEUTICALS INC. (US) | 1991-08-14 | — | — | EP | disclosed |
| US-5011835-A | Substituted triazolopyridazines, pharmaceutical compositions and use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-30 | — | — | US | disclosed |